肝动脉化疗栓塞联合调强放疗治疗原发性肝癌的临床疗效  

Clinical Analysis of Transcatheter Arterial Chemoembolization Combined with Intensity Modulated Radiotherapy Therapy for Patients with Primary Hepatic Carcinoma

作　　者：高靖琰 陈富坤[2] 鄢佳文[1] 王家平[2] 

机构地区：[1]昆明医科大学第三附属医院放射治疗中心,云南昆明650118 [2]昆明医科大学第二附属医院介入室,云南昆明650101

出　　处：《昆明医科大学学报》2017年第1期95-98,共4页Journal of Kunming Medical University

基　　金：云南省科技厅应用基础研究基金资助项目(2009ZC111M);云南省教育厅科学研究基金资助项目(09Z0034)

摘　　要：目的评价肝动脉化疗栓塞(TACE)联合调强放疗(IMRT)治疗肝癌的疗效.方法符合入组条件的原发性肝癌(PHC)患者68例随机分为治疗组(TACE联合IMRT)34例和对照组(单纯TACE)34例,对照组采用单纯TACE治疗.治疗组先行2~3次TACE治疗,在介入治疗治疗后2~4周后行放射治疗.结果治疗组近期有效率为82.4%显著高于对照组61.8%(P<0.05);治疗组与对照组1 a、2 a生存率分别为76.5%、55.9%、和58.9%、32.4%,2组生存率比较差异有统计学意义(P<0.05).2组均无严重毒副反应发生.结论TACE联合IMRT治疗原发性肝癌较单纯介入治疗明显提高治疗效果,患者耐受性良好,无严重的远期并发症.Objective To evaluate the efficacy of transcatheter arterial chemoembolization （TACE） in combination with intensity modulated radiotherapy （IMRT） in treatment of primary hepatic carcinoma （PHC）. Methods All 68 patients with PHC were randomized into treatment group （TACE plus IMRT） and control group （TACE alone） , with 34 cases in each group. Patients in the control group were treated with interventional therapy alone. Patients in the treatment group were treated with interventional therapy （transcatheter arterial chemoem- bolization） plus radiotherapy. Treatment group patients firstly received 2 to 3 times interventional therapy, then followed by radiotherapy with 2 to 4 week interval. Results The short-term efficacy was 82.4% in treatment group which was significantly higher than 61.8% in control group （P〈O.05）. The survival rate was 76.5% in 1 year and 55.9% in 2 years in treatment group, 58.9% and 32.4% in control group respectively. The difference between 2 group was statistical significance （P〈0.05） No serious toxieities were observes in the patients of the two groups. Conclusion The results suggest that the treatment effect of TACE plus IMRT is better than interventional therapy alone for patients with primary Hepatic carcinoma, and has well tolerance and fewer adverse reactions.

关 键 词：原发性肝癌 放射疗法 介入疗法 肝动脉化疗栓塞 调强放射治疗 

分 类 号：R735.7[医药卫生—肿瘤]