血清CA125、HE4联合阴道彩色多普勒在卵巢癌高危人群早期筛查中的临床价值  

Clinical value of serum CA125 and HE4 combined with vaginal color Doppler in early screening of ovarian cancer among high-risk populations

作　　者：辜卫红[1] 胡天惠[1] 薛涛[2] 

机构地区：[1]江苏省淮安市妇幼保健院更年期门诊,223003 [2]江苏省淮安市妇幼保健院麻醉科,223003

出　　处：《重庆医学》2017年第12期1613-1615,共3页Chongqing medicine

基　　金：江苏省淮安市科技计划项目--应用研究与科技攻关计划(社会发展)课题基金(HAS2014)

摘　　要：目的探讨血清癌胚抗原125(CA125)、人附睾蛋白4(HE4)联合阴道彩色多普勒检查在卵巢癌高危人群早期筛查中的临床价值。方法将纳入研究的对象分为3组:健康组100例,高危组80例,卵巢癌组32例。对比3组血清CA125、HE4水平及超声评分。结果卵巢癌组HE4和CA125水平及超声评分较其他两组明显升高,差异有统计学意义(P<0.01);高危组的阳性检出率及CA125水平均高于健康组,差异均有统计学意义(P<0.05);高危组中,CA125、HE4联合超声的阳性检出率均高于其他检测方法(P<0.05);CA125+HE4联合阴道超声筛查的敏感性及特异性明显高于其他筛查方法,差异有统计学意义(P<0.05);HE4特异性明显高于CA125,但敏感性低于CA125(P<0.05)。结论 CA125、HE4联合阴道超声检查有利于提高卵巢癌高危人群的早期筛查,便于节约医疗成本,提高检出率。Objective To explore the clinical value of serum CA125 and HE4 combined with transvaginal color Doppler （TVCD） examination in early screening of ovarian cancer among high-risk populations. Methods The included research subjects were divided into 3 groups： 100 cases in the healthy group,80 cases in the high-risk group and 32 cases in the ovarian cancer group. The serum CA125 and HE4 levels and ultrasonic scores were compared among 3 groups. Results The HE4 and CA125 levels and ultrasound scores in the ovarian cancer group were significantly increased compared with the other two groups,the difference was statistically significant （P〈0.01）;the positive detection rate of CA125 plus HE4 levels combined with ultrasonic examination in the high-risk group was higher than that of other detection method （P〈0. 05） ;the sensitivity and specificity of CA125 ＋ HE4 combined with vaginal ultrasound screening were obviously higher than those of other screening method, the difference was statistically significant （P〈0.05） ;the specificity of HE4 was significantly higher than that of CA125 ,but its sensitivity was lower than that of CA125 （P〈0. 05）. Conclusion CA125 and HE4 combined with TVCD is helpful for early screening of ovarian cancer in high-risk populations, easy to save medical cost and improves its detection rate.

关 键 词：卵巢癌高危人群 CA125 HE4 阴道 超声检查 多普勒 彩色 

分 类 号：R737.31[医药卫生—肿瘤]