IL-17、IL-23在接受利妥昔单抗治疗的B细胞非霍奇金淋巴瘤患者中的表达  

Expression of IL-17 and IL-23 in Patients with B-cell non-HodgkinLymphoma Treated by RCHOP

作　　者：黄颖[1] 刘熠晗 黎承平[1] 武坤[1] 曾云[1] 

机构地区：[1]昆明医科大学第一附属医院血液科,云南昆明650032

出　　处：《昆明医科大学学报》2016年第12期76-81,共6页Journal of Kunming Medical University

基　　金：云南省教育厅科学研究基金资助项目(2013Y292)

摘　　要：目的检测B细胞非霍奇金淋巴瘤（non-Hodgkin lymphoma，NHL）患者治疗前后IL-17、IL-23表达水平的变化，探讨IL-17、IL-23在NHL发生发展过程中的作用．方法应用逆转录一聚合酶链式反应（re-verse transeription-polymerase chain reaction，RT-PCR）法检测25例接受标准剂量R-CHOP方治疗6-8个疗程的B细胞NHL患者和20例健康对照组．结果NHL患者初诊时和缓解时外周血中IL-17mRNA的表达水平均低于健康对照组（P〈0．05）．NHL患者缓解时与初诊时相比，IL-17mRNA的表达水平有所升高（P=0．001，P〈0．05）．NHL患者初诊时和缓解时外周血中IL-23mRNA的表达水平均低于健康对照组（P〈0．05）．缓解时与初诊时相比，IL-23mRNA的表达水平升高，（P=0．004，P〈0．05）．结论B细胞非霍奇金淋巴瘤患者接受利妥昔单抗治疗后IL-17、IL-23水平升高．IL-17、IL-23mRNA的表达与预后相关．Objectives To study the role of IL-17 and 1L-23 in non-Hodgkin lymphoma （NHL） by detecting the expression levels of IL-17 and IL-23 in peripheral blood of B-cell non-Hodgkin lymphoma patients treated by RCHOP. Methods T wenty-five patients with B-cell NHL who achieved remission after 6 to 8 cycles of R-CHOP as a NHL group, 20 healthy volunteers were recruited as a normal control group. RT-PCR was used to detect the expression levels of IL-17 mRNA and IL-23mRNA in NHL patients and health volunteers. Results The expression level of IL-17mRNA andIL-23 mRNAin the patients with NHL before therapy and the patients with NHL who achieved remission was Rower than that in the normal control group （P〈0.05）. The expression level of IL-I？mRNA andIL-23mRNA in the patients with NHL who achieved remission was higher than that in the patients with NHL before therapy （P=0.001, P〈0.05）. Conclusion 1L-17 and IL-23mRNA expressions are higher after treated with R-CHOP. The expression levels of IL-17 mRNA and IL-23 mRNA in NHL patients are related with prognosis and efficacy.

关 键 词：非霍奇金淋巴瘤 白介素-17 白介素-23 利妥昔单抗 预后 

分 类 号：R733.1[医药卫生—肿瘤]