未服药双相抑郁与单相抑郁患者前扣带回部位大脑代谢物水平的比较  

Comparison of Neurometabolite Levels in Anterior Cingulate Cortex of Medication-free Individuals with Bipolar and those with Unipolar Depression

作　　者：李慧[1,2] 张印南[1] 关计添[2] 章杰[1] 沈智威[2] 张金玲[1] 吴仁华[2] LI Hui ZHANG Yin-nan GUAN Ji-tian ZHANG Jie SHEN Zhi-wei ZHANG Jin-ling WU Ren-hua(Mental Health Center of Shantou University, Shantou 515041, China Department of Medical Imaging, The Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, China)

机构地区：[1]汕头大学精神卫生中心 [2]汕头大学医学院第二附属医院影像科,广东汕头515041

出　　处：《汕头大学医学院学报》2017年第1期17-19,共3页Journal of Shantou University Medical College

基　　金：国家自然科学基金资助项目(81471730);广东省医学科研基金资助项目(A2014459;A2015232)

摘　　要：目的:比较双、单相抑郁患者前扣带回部位大脑代谢物水平。方法:用氢质子磁共振频谱技术检测双、单相抑郁和正常对照组(各组11例)大脑前扣带回部位代谢物水平。联合运用LCModel和SAGE软件对前扣带回部位的代谢物进行定量。结果:双相抑郁组在前扣带回部位谷氨酸+谷氨酰胺水平较正常对照和单相抑郁组均升高。前扣带回部位N-乙酰基天门冬氨酸、肌酸、胆碱、肌醇在三组被试间均无统计学意义。结论:双相抑郁在前扣带回部位存在谷氨酸系统失衡,而单相抑郁则否。这可能是两种疾病不同病理生理学机制。Objective：To compare the metabolite levels in anterior cingulate cortex of bipolar and unipolar depression patients.Methods：The bipolar and unipolardepression patients and healthy controls（11 cases in each group）underwent routine MRI scan and protonmagnetic resonance spectrosco-py.The absolute metabolite concentrations in anterior cingulat ecortex（ACC） were measured using LCModel and SAGE software.Results：The bipolar depression group showed significantly higher levels of Glx in their ACC compared with uinpolar depression and control groups.No difference in other brain metabolites among groups.Conclusion：There is glutamate system imbalance in ACC of bipolar depression,while not in unipolar depression.This indicates there may be different pathophysiology between two diseases.

关 键 词：双相抑郁 单相抑郁 磁共振频谱 谷氨酸 

分 类 号：R749.4[医药卫生—神经病学与精神病学]