实验性1型糖尿病大鼠牙槽骨高度变化研究  

The study of alveolar bone height changes in experimental type 1 diabetic rats

作　　者：孙尚敏[1] 闫露[1] 潘亚萍[1] 林莉[1] 潘春玲[1] 唐晓琳[1] SUN Shang-min YAN Lu PAN Ya-ping LIN Li PAN Chun- ling TANG Xiao- lin.(Department of Periodontics, School of Stomatology , China Medical University, Laboratory of Periodontics , Liaoning Institute of Dental Research, Shea yang 110002, China)

机构地区：[1]中国医科大学口腔医学院·附属口腔医院牙周病科,辽宁省口腔医学研究所牙周病研究室,辽宁沈阳110002

出　　处：《中国实用口腔科杂志》2017年第3期171-174,共4页Chinese Journal of Practical Stomatology

基　　金：辽宁省科学技术计划项目(2013225303)

摘　　要：目的探讨实验性1型糖尿病大鼠牙槽骨高度的变化。方法选取SPF级雄性Sprague-Dawley(SD)大鼠12只,随机分为实验组和对照组,每组6只。实验组大鼠腹腔一次性注射新鲜配制的链脲佐菌素(STZ)(60 mg/kg)建立1型糖尿病模型;对照组大鼠注射相应体积的柠檬酸盐缓冲液。观察8周,然后处死所有大鼠并分离其上下颌骨,体式显微镜观察测量上下颌骨第一、二、三磨牙的牙槽骨高度,比较分析牙槽骨高度的变化。结果对照组大鼠未见明显的牙槽骨破坏;实验组大鼠可见明显的牙槽骨破坏,破坏呈水平型,第一、二、三磨牙牙槽骨均有破坏,与对照组相比差异有统计学意义(P<0.05)。结论实验性1型糖尿病大鼠可见牙槽骨破坏,并且呈现缓慢的水平型吸收。Objective To explore the alveolar bone height changes in experimental type 1 diabetic rats. Methods Twelve male Sprague-Dawley （SD） rats were randomly divided into experimental and control groups. The rats in the experimental groups were made type 1 diabetes mellitus （DM）by intraperitoneal injection of streptozotocin （STZ） （60mg/ kg）, while the control groups were injected with equal volume citrate buffer. All animals were sacrificed after 8 weeks. The alveolar bone loss （ABL） of the first molar, second molar and the third molar were measured from alveolar crest to enamel-cementum junction by stereoscope loupe. Results The rats in the control groups had no obvious bone damage ; while experimental groups showed obvious bone destruction horizontally, there was significant difference statistically （P 〈 0.05 ）. Conclusion The alveolar bone damage was shown in rats with type 1 diabetes mellitus, and was horizontal absorption slowly.

关 键 词：糖尿病 牙槽骨 链脲佐菌素 

分 类 号：R78[医药卫生—口腔医学]