联用黛力新治疗功能性消化不良的疗效分析  

Analysis of Deanxit-combined Treatment of Functional Dyspepsia

作　　者：马红晶 缪应雷[2] MA Hong-jing MIAO Ying-lei(The Third People＇s Hospital of Yuxi, Yuxi Yunnan 653100 The 1st Affiliated Hospital of Kunming Medical University, Kunming Yunnan 650031, China)

机构地区：[1]玉溪市第三人民医院,云南玉溪653100 [2]昆明医科大学第一附属医院,云南昆明650032

出　　处：《昆明医科大学学报》2016年第8期72-74,共3页Journal of Kunming Medical University

基　　金：国家自然科学基金资助项目(81260074;81160055)

摘　　要：目的探讨常规治疗联用黛力新改善功能性消化不良（FD）的消化道症状、睡眠疗效及安全性.方法将90例FD患者随机分为对照组（泮托拉唑胶囊＋莫沙必利胶囊＋对伴睡眠障碍者加用艾司唑仑片）和观察组（泮托拉唑胶囊＋莫沙必利胶囊＋对伴睡眠障碍者加用艾司唑仑片＋黛力新）,疗程均为4周.疗程结束后,比较2组消化道症状、睡眠的改善程度及不良反应.结果治疗4周后,观察组消化道症状改善总有效率86.7%,高于对照组66.7%,差异有统计学意义（P〈0.05）;睡眠障碍改善总有效率83.3%、高于对照组61.9%,但差异无统计学意义（P〉0.05）;2组不良反应发生率无差异（P〉0.05）.结论常规治疗基础上,联用黛力新治疗FD能显著改善患者的消化道症状,用药后约3～7 d观察症状出现改善趋势,4周时症状改善总有效率最高,不良反应少,可在临床应用推广.Objective To investigate the improvement and safety of the conventional treatment combined with Deanxit in the treatment of digestive adverse（FD） of gastrointestinal symptoms and sleep efficacy. Methods Ninety cases of patients with FD were randomly divided into the control group（pantoprazole capsule and Mosapride will ＋ Capsule associated with sleep disorders with estazolam tablets） and observation group（pantoprazole capsule and Mosapride will ＋ capsule with sleep disorders and estazolam tablets plus Deanxit）.Both groups were treated for 4 weeks. After the course of treatment, the improvement degree and adverse reaction of digestive tract symptoms and sleep were compared between the two groups.Results After 4 weeks of treatment in the observation group with gastrointestinal symptoms were improved and the total effective rate was 86.7%, higher than that of the control group（66.7%）.The difference was statistically gigmificart（P 〈0.05）. The total effective rate of was sleep disorders improvement 83.3%, higher than that of control group（61.9%）, but the difference was not statistically significant（P 〉 0.05）.Adverse reaction rates were not significantly different between the two groups. Conclusion On the basis of conventional therapy, treatment of functional dyspepsia（FD） with Deanxit can significantly alleviate gastrointestinal symptoms.Medication after3-7 days can relieve the symptoms. After 4 weeks, the total efficiency is the highest with fewer adverse reactions.Clinical application is recommended.

关 键 词：功能性消化不良 氟哌噻吨美利曲辛片 抗抑郁焦虑药 

分 类 号：R57[医药卫生—消化系统]