重型颅脑损伤患者围术期神经功能与红细胞免疫指标的变化  

Study on the Change of Nerve Function and Erythrocyte Immune Indexes of Patients with Severe Craniocerebral injury During the Perioperative Period

作　　者：范寿成[1] 苏洪亮[1] 陶汝通 杨航[1] 蒲军[2] FAN Shou-cheng SU Hong-liang TAO Ru-tong YANG Hang PU Jun(Dept. of Neurosurgery, People＇s Hospital of Xishuang Bah＇ha Autonomous Prefecture, Jinghong Yunnan 666100 ） Dept. of Neurosurgery, The Second Affiliated Hospital of Kunming Medical University, Kunming Yunnan 650101, China)

机构地区：[1]西双版纳州人民医院神经外科,云南景洪666100 [2]昆明医科大学第二附属医院神经外科,云南昆明650101

出　　处：《昆明医科大学学报》2016年第9期62-65,共4页Journal of Kunming Medical University

基　　金：国家自然科学基金资助项目(81460174);云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目(2013FB156)

摘　　要：目的研究重型颅脑损伤患者围术期神经功能与红细胞免疫指标的变化情况.方法选取2013年7月至2015年8月于西双版纳州人民医院进行手术治疗的40例重型颅脑损伤患者为观察组,同时采用40名同龄健康者为对照组,然后将观察组术前及术后1 d、3 d、5 d、7 d、10 d及14 d和对照组的神经功能相关指标与红细胞免疫指标进行比较.结果观察组术前及术后1 d、3 d、5 d、7 d、10 d及14 d神经功能相关血清指标均高于对照组(P<0.05),观察组术前及术后1 d、3 d、5 d、7 d、10 d的红细胞免疫指标均差于对照组(P<0.05),术后5 d及7 d的红细胞免疫指标差于术前、术后1 d、3 d、10 d及14 d,P<0.05.比较指标间均有显著性差异(P<0.05).结论重型颅脑损伤患者围术期神经功能与红细胞免疫指标的变化较大,应给予此类患者上述指标以充分的监测及干预.Objective To study and observe the change of nerve function and erythrocyte immune indexes of patients with severe craniocerebral injury during the perioperative period. Methods Forty patients with severe craniocerebral injury treated with surgery in our hospital from July 2013 to August 2015 were selected as the observation group and 40 healthy persons with the same ages in the same period were selected as the control group.The nerve function related indexes and erythrocyte immune indexes of observation group before and at first,third,fifth,seventh,tenth and fourteenth day after the surgery and those of control group were compared. Results The serum nerve function related indexes of observation group before and at first, third, fifth, seventh, tenth and fourteenth day after the surgery were higher than those of control group. The erythrocyte immune indexes of observation group before and at first,third,fifth,seventh and tenth day after the surgery were worse than those of control group. The erythrocyte immune indexes at fifth and seventh day after the surgery were worse than those before and at first,third,third,tenth and fourteenth day after the surgery. The differences of comparison indexes were all significant（P〈0.05）. Conclusion The change of nerve function and erythrocyte immune indexes of patients with severe craniocerebral injury during the perioperative period are obvious. Those indexes should be paid withenough monitoring and intervention.

关 键 词：重型颅脑损伤 围术期 神经功能 红细胞免疫指标 

分 类 号：R743.3[医药卫生—神经病学与精神病学]