脑深部电刺激术治疗帕金森病40例报道  

Analysis of Effectiveness of Deep Brain Stimulation for Forty Cases of Parkinson's Disease

作　　者：施国林 周明锐[1] 张加初 赵宁辉[1] 孙伯民[1,2] SHI Guo-li ZHOU Ming-rui ZHANG Jia-chu ZHAO Ning-hui SUN Bo-ming(） Dept. of Functional Neurosurgery, The 2nd Affiliated Hospital of Kunming Medical University, Kuming Yunnan 650101 ） Dept.of Functlonal Neurosurgery, Ruij＇in Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai200021, China)

机构地区：[1]昆明医科大学第二附属医院功能神经外科,云南昆明650101 [2]上海交通大学医学院附属瑞金医院功能神经外科,上海200021

出　　处：《昆明医科大学学报》2016年第9期113-115,共3页Journal of Kunming Medical University

基　　金：云南省高端科技人才引进计划基金资助项目(2012HA011);云南省中青年学术技术带头人后备人才基金资助项目(2009CI034);云南省卫生厅卫生系统学科带头人培养计划基金资助项目(D-201221)

摘　　要：目的探讨脑深部电刺激术(DBS)治疗帕金森氏病的临床疗效.方法对2014年3月至2015年8月在昆明医科大学第二附属医院功能神经外科行脑深部电刺激术的40例帕金森氏病病例进行分析,对比患者手术前后临床症状的改善情况,并进行UPDRS评分.结果接受脑深部电刺激手术治疗后患者肌肉僵直、静止性震颤、运动迟缓等症状改善明显,术后UPDRS评分降低,术后口服美多芭、息宁等药物用量减少,出现异动症等并发症的患者症状明显控制.结论脑深部电刺激术治疗帕金森氏病安全有效,可明显控制患者症状,减少口服药物用量,提高生活质量.Objective To investigate the effectiveness of deep brain stimulation（DBS） treating Parkinson＇s disease. Methods Forty cases of Parkinson＇s disease were selected from March 2014 to August 2015. The clinical symptoms of these patients were described and quantitatively analyzed with Unified Parkinson＇s Disease Rating Scale（UPDRS） before and after the procedure of DBS surgery. Results After deep brain stimulation surgery, the symptoms including muscle stiffness, static tremor, bradykinesia were improved,UPDRS scores were significantly lower and the demanding dosage of Parkinson disease drugs such as L-dopa/benserazide and L-dopa/carbidopa were also reduced. Conclusion Deep brain stimulation for Parkinson＇s disease is safe and effective. It can obviously control the symptoms, reduce the dosage of oral drugs, and improve the quality of life.

关 键 词：帕金森氏病 脑深部电刺激术 丘脑底核 苍白球内侧部 

分 类 号：R742[医药卫生—神经病学与精神病学]