幽门螺杆菌致病因子及其致病机制研究进展  

Virulence factors and pathogenic mechanism of Helicobacter pylori

作　　者：杨成[1] 崔梅花[1,2] 

机构地区：[1]航天中心医院消化科,北京市100049 [2]北京大学航天临床医学院消化科,北京市100049

出　　处：《世界华人消化杂志》2017年第10期857-864,共8页World Chinese Journal of Digestology

摘　　要：幽门螺杆菌(Helicobacter pylori,H.pylori)与慢性胃炎、消化性溃疡、胃黏膜相关淋巴样组织淋巴瘤、胃癌等疾病密切相关.H.pylori致病性主要依赖于其鞭毛、螺旋结构、脂多糖、细胞毒素相关蛋白和空泡毒素等多种致病因子,通过复杂的致病机制最终导致疾病.本文结合国内外文献综述H.pylori致病因子及其致病机制的最新研究进展.Helicobacter pylori（H.pylori） is closely related with some diseases such as chronic gastritis,peptic ulcer,gastric mucosa associated lymphoid tissue lymphoma,and gastric cancer.The pathogenicity of H.pylori mainly relies on its flagellum,spiral structure,lipopolysaccharide,cytotoxin associated protein A,and vacuolating cytotoxin A.Through complex pathogenic mechanisms,H.pylori causes various kinds of diseases.In this paper,we discuss the latest research progress in the understanding of the virulence factors and pathogenic mechanism of H.pylori.

关 键 词：幽门螺杆菌 致病因子 致病机制 

分 类 号：R573[医药卫生—消化系统]