美沙拉嗪对溃疡性结肠炎患者血清炎症因子与凝血指标的影响  

Effects of Mesalazine on the Serum Inflammatory Cytokines and Coagulation Parameters of Patients with Ulcerative Colitis

作　　者：李韶华[1] 王新[1] 李亚妮[1] 柯小茹 谢华红[1] LI Shao-hua WANG Xin LI Ya-ni KE Xiao-ru XIE Hua-hong(Department of internal medicine, Xijing Hospital, The Fourth Military Medical University, Xi＇an, Shaanxi, 710032, China)

机构地区：[1]第四军医大学西京医院消化内科,陕西西安710032

出　　处：《现代生物医学进展》2017年第11期2050-2053,共4页Progress in Modern Biomedicine

基　　金：陕西省自然科学基金项目(13080M120)

摘　　要：目的:分析美沙拉嗪对溃疡性结肠炎患者血清炎症因子与凝血指标的影响。方法:按抽签法将102例溃疡性结肠炎患者分作对照组和研究组,各51例,对照组治疗采用柳氮磺胺吡啶,研究组治疗采用美沙拉嗪,观察两组治疗前后血清白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子α(TNF-α),血小板(PLT)、纤维蛋白原(Fg)、凝血酶原时间(PT)、D-二聚体(D-D)水平,氧化应激指标,免疫功能,临床疗效及安全性。结果:治疗后,研究组患者血清IL-1β、IL-6、IL-8、TNF-α、Fg、D-D水平及PLT均显著低于对照组,PT高于对照组,差异有统计学意义(P<0.05)。研究组氧化应激过氧化脂质(LPO)、丙二醛(MDA)、超氧化物歧化酶(SOD)、免疫功能(CD3^+、CD4^+、CD8^+、CD4^+/CD8^+)改善均优于对照组(P<0.05)。研究组总有效率高于对照组,不良反应率低于对照组,均有统计学差异(P<0.05)。结论:美沙拉嗪治疗溃疡性结肠炎患者可显著抑制炎症,改善氧化应激状态,纠正凝血功能障碍并改善免疫功能,且临床疗效和安全性均较好。Objective： To analyze the effects of mesalazine on the serum inflammatory cytokines and coagulation parameters of patients with ulcerative colitis. Methods： 102 patients with ulcerative colitis were divided into the control group and the treatment group by lottery method with 51 cases in each group, the control group was treated by willow sulfasalazine, while the treatment group was treated by mesalazine, the serum interleukin 1β（IL-1β）, interleukin-6 （IL-6）, interleukin-8 （IL-8）, tumor necrosis factor-α（TNF-α, platelet（PLT）, fibrinogen （Fg）, prothrombin time（PT）, D-dimer（D-D）, oxidative stress indicators, immune function, clinical curative effect and security were observed and compared between two groups after treatment. Results： After treatment, the serum IL-1β, IL-6, IL-8, TNF-alpha, PLT, Fg, D-D levels of treatment group were lower than those of the control group, PT was higher than that of the control group （P〈0.05）. The improvement of oxidative stress lipid peroxide （LPO） and malondialdehyde （MDA）, superoxide dismutase （SOD）, immune function （CD3^＋, CD4^＋, CD8^＋, CD4^＋/CD8^＋） of treatment group were better than those of the control group （P〈0.05）. The total effective rate of treat- ment group was higher than that of the control group, the adverse reaction rate was lower than that of the control group（P〈0.05）. Conclu- sion： Mesalazine could significantly inhibit the inflammatory response, improve the oxidative stress, coagulation disorders and immune function of patients with ulcerative colitis with good clinical efficacy and safety.

关 键 词：疡性结肠炎 美沙拉嗪 炎症因子 凝血指标 

分 类 号：R574.62[医药卫生—消化系统]