2型糖尿病人群肝功能异常影响因素分析  

Analysis on influencing factors of type 2 diabetes mellitus with liver dysfunction

作　　者：张正[1] 孙中明[1] 张芹[1] 缪丹丹[1] 于浩[2] 苏明 潘恩春[1] 

机构地区：[1]淮安市疾病预防控制中心慢病科,江苏省淮安223001 [2]淮安市清河区疾病预防控制中心慢病科 [3]淮安市淮安区疾病预防控制中心慢病科

出　　处：《中国慢性病预防与控制》2017年第2期81-84,共4页Chinese Journal of Prevention and Control of Chronic Diseases

基　　金：江苏省卫生厅医学创新团队科技项目(K201105);2013年度省第四期"333工程"科研资助立项项目(BRA2013107)

摘　　要：目的探讨2型糖尿病人群肝功能异常的影响因素,为其预防控制措施提供理论依据。方法于2014年对淮安市清河区和淮安区在社区管理的2型糖尿病人群开展问卷调查、体格测量和生化检验。用SPSS 19.0对研究因素进行单因素及多因素logistic回归分析。结果本次调查共纳入2型糖尿病患者9 773例,发现肝功能异常2 385例,异常率为24.4%。单因素logistic回归分析得出性别、年龄、居住地、吸烟、饮酒、饮茶、口服降糖药、控制饮食、加强运动、高血压、高血脂、冠心病和脑卒中13个有统计学意义的影响因素,多因素logistic回归结果显示,性别(OR=1.924,95%CI:1.706~2.170)、年龄(OR=2.107,95%CI:1.774~2.503)、居住地(OR=1.592,95%CI:1.417~1.788)、饮酒(OR=1.252,95%CI:1.098~1.427)、高血压(OR=1.393,95%CI:1.257~1.544)、高血脂(OR=1.235,95%CI:1.095~1.392)和脑卒中(OR=1.172,95%CI:1.017~1.356)是2型糖尿病人群肝功能异常的危险因素,而饮茶(OR=0.829,95%CI:0.724~0.950)、口服降糖药(OR=0.868,95%CI:0.783~0.963)是保护因素。结论 2型糖尿病人群肝功能异常率较高,受到多危险因素共同影响,建议针对危险因素采取有效的干预控制措施以减少2型糖尿病人群肝功能异常的发生。Objective To explore the influencing factors of type 2 diabetes mellitus （T2DM） with liver dysfunction and to provide the evidences for prevention measures. Methods In 2014, the investigation of T2DM patients from Qinghe district and Huai ＇an district of Huai＇an city was performed by the questionnaire, physical examination and biochemical test. The univariate and multivariate logistic regression methods were used to analyze the influencing factors with SPSS 19.0 software. Results Among 9 773 T2DM patients in present study, the proportion of T2DM with liver dysfunction was 24.4% （2 385 cases）. The univariate logistic regression analysis showed that 13 influencing factors. The multivariate logistic regression analysis displayed that gender （OR=1.924, 95%CI： 1.706-2.170）, age （OR=2.107, 95%CI： 1.774-2.503）, residence （OR=1.592, 95%CI： 1.417-1.788）, drinking alcohol （0R=1.252, 95%CI： 1.098-1.427）, hypertension （OR=1.393, 95%CI： 1.257-1.544）, hyperlipidemia （OR= 1.235, 95%CI： 1.095-1.392）, stroke （OR=1.172, 95%CI： 1.017~1.356） were risk factors for T2DM with liver dysfunction; but drinking tea （OR=0.829, 95%CI： 0.724-0.950）, oral antidiabetie drugs （OR=0.868, 95%CI： 0.783-0.963 ） were protective factors for T2DM with liver dysfunction. Conclusion The proportion of liver dysfunction in T2DM patients is higher and impacted by many risk factors. Some intervention measures according to the influencing factors should be taken to reduce the occurrence of liver dysfunction in T2DM patients.

关 键 词：糖尿病 2型 肝功能异常 影响因素 

分 类 号：R735.1[医药卫生—肿瘤]