喹硫平联合帕罗西汀治疗双相抑郁障碍的疗效观察  

Observation of efficacy of quetiapine combined with paroxetine in the treatment of bipolar depression

作　　者：陈倩倩[1] 曹敏敏[1] 齐文耀 汤义平[1] 

机构地区：[1]台州市第二人民医院心身科,浙江省台州317200

出　　处：《中国基层医药》2017年第8期1250-1253,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 探讨喹硫平联合帕罗西汀治疗双相抑郁障碍的疗效,为临床治疗方案的选择提供参考.方法 选取双相抑郁障碍患者96例,采用随机数字表法分为观察组和对照组各48例.对照组采用喹硫平口服,观察组采用喹硫平联合帕罗西汀口服,治疗6周后对比两组患者的临床疗效、治疗前后蒙哥马利抑郁评定量表和贝克-拉范森躁狂量表的评分结果;同时对比两组患者的不良反应发生情况.结果 观察组治疗6周后的总有效率为70.83％,显著高于对照组（50.00％）,差异有统计学意义（χ^2=4.356,P=0.037）;观察组治疗6周后的蒙哥马利抑郁评定量表评分结果为（14.01 ±2.95）分,显著低于对照组（18.07 ±3.05）分,差异有统计学意义（t=5.527,P=0.036）;两组患者治疗前后贝克-拉范森躁狂量表评分结果的对比,差异均无统计学意义;两组患者治疗过程中均未发生严重不良反应.结论 喹硫平联合帕罗西汀可有效抑制双相抑郁发作,同时避免诱发躁狂发作,具有良好的临床疗效,且安全性高,值得推广应用.Objective To explore the curative effect of quetiapine combined with paroxetine in the treatment of bipolar depression,and to provide reference for the choice of clinical treatment.Methods According to the digital table,96 patients with bipolar disorder were randomly divided into observation group and control group,48 cases in each group.The control group was treated with quetiapine orally,the observation group was treated with quetiapine combined with paroxetine.After 6 weeks of treatment,the clinical curative effect,the Montgomery Asberg Depression Rating Scale and the Beck pull fan Sen Mania Rating table score before and after treatment were compared between the two groups.At the same time,the adverse reactions of the two groups were compared.Results After 6 weeks of treatment,the total effective rate of the observation group was 70.83%,which was significantly higher than 50.00% in the control group,the difference was statistically significant（χ^2 =4.356,P =0.037）.After 6 weeks of treatment,the Montgomery Asberg Depression Rating quantity score in the observation group was （14.01 ± 2.95） points,which was significantly lower than （18.07 ± 3.05）points in the control group,the difference was statistically significant （t =5.527,P =0.036）.The Baker-pull fan Sen Mania Rating score before and after treatment between the two groups had no statistically significant differences.There were no serious adverse reactions in the two groups.Conclusion Quetiapine combined with paroxetine can effectively inhibit bipolar depressive episodes,avoid manic episodes,has good clinical efficacy and high safety,it is worthy of popularization and application.

关 键 词：喹硫平 帕罗西汀 双相抑郁障碍 疗效 

分 类 号：R749.4[医药卫生—神经病学与精神病学]