食管鳞癌组织内皮素-1和E-钙黏蛋白的表达  

EXPRESSIONS OF ENDOTHELIN-1 AND E-CADHERIN IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA

作　　者：尹辉[1] 姜长青[2] 沈毅[3] 矫文捷[3] 李飞[1] 王伦青[1] 

机构地区：[1]青岛大学附属青岛市市立医院胸外科,山东青岛266011 [2]青岛大学附属青岛市市立医院病理科 [3]青岛大学附属医院胸外科

出　　处：《齐鲁医学杂志》2017年第1期10-13,共4页Medical Journal of Qilu

摘　　要：目的探讨食管鳞状细胞癌组织内皮素-1和E-钙黏蛋白的表达水平,并分析两者之间关系。方法应用免疫组织化学技术,检测58例食管鳞癌组织及相应癌旁正常食管组织内皮素-1和E-钙黏蛋白的表达情况。结果食管鳞癌组织内皮素-1和E-钙黏蛋白的阳性表达与浸润深度、周围淋巴结转移与否、分化程度有关(Z=6.908~14.973,P<0.05);食管鳞癌组织和相应癌旁正常食管组织中内皮素-1的阳性表达率分别为12.07%(7/58)和77.59%(45/58),E-钙黏蛋白的阳性表达率分别为82.76%(48/58)和41.38%(24/58),两组两种指标比较差异有显著性(Z=-7.161、-5.593,P<0.01)。食管鳞癌组织内皮素-1和E-钙黏蛋白表达呈负相关(r=-0.525,P<0.01)。结论食管鳞癌组织中内皮素-1呈高表达、E-钙黏蛋白呈低表达,二者对食管鳞癌的发生发展可能存在反向调节作用。Objective To investigate the expressions of Endothelin-1（ET-1）and E-cadherin,and their correlation,in esophageal squamous cell carcinoma（ESCC）. Methods Employing immuno-histochemical technique,expressions of Endothelin-1and E-cadherin in 58 cases of ESCC tissue and corresponding adjacent normal mucosa were detected. Results In the cancer tissue,expressions of ET-1and E-cadherin were correlated with invasion depth,peripheral lymph node metastasis,and differentiation degree（Z=6.908-14.973,P〈0.05）.The positive expression of ET-1in tissue of ESCC and adjacent normal tissue was 12.07%（7/58）and 77.59%（45/58）,respectively,and that of E-cadherin was 82.76%（48/58）and 41.37%（24/58）,respectively,a comparison between the two indicators of the two groups being significant（Z=-7.161,-5.593;P〈0.01）.In tissue of ESCC,ET-1expression was negatively correlated with E-cadherin（r=-0.525,P〈0.01）. Conclusion In tissue of esophageal squamous cell cacinoma,the high expression of ET-1and low expression of E-cadherin are likely to play an opposite regulation on the occurrence and development of ESCC.

关 键 词：内皮素1 钙黏蛋白 食管鳞癌 免疫组织化学 

分 类 号：R735.1[医药卫生—肿瘤]