鼻咽癌组织p-eIF4E和p-4EBP1高表达与预后不良正相关  

Over-expressions of p-eIF4E and p-4EBP1 are associated with poor prognosis in nasopharyngeal carcinoma

作　　者：郑军[1,2] 张春燕[3] 张毅强[1] 裴晋红[1] 范松青[2] 

机构地区：[1]山西省长治医学院生化教研室,山西长治046000 [2]湖南省中南大学湘雅二医院病理科,湖南长沙410011 [3]山西省长治医学院附属和平医院妇科,山西长治046000

出　　处：《细胞与分子免疫学杂志》2017年第4期531-535,共5页Chinese Journal of Cellular and Molecular Immunology

基　　金：长治医学院科技创新项目(CX201502)

摘　　要：目的探讨磷酸化的真核细胞翻译起始因子4E(p-eIF4E)和磷酸化的eIF4E结合蛋白1(p-4EBP1)与鼻咽癌(NPC)临床病理特征和预后的相关性。方法免疫组织化学染色法检测314例NPC组织中p-eIF4E和p-4EBP1蛋白表达,利用SPSS16.0软件分析p-eIF4E和p-4EBP1蛋白表达与NPC临床病理特征及预后的相关性。结果 NPC组织中存在p-eIF4E和p-4EBP1蛋白异常高表达,阳性表达率分别为74.2%(233/314)、72.9%(229/314);p-eIF4E和p-4EBP1蛋白表达在淋巴结转移NPC组织中阳性表达率显著高于无淋巴结转移NPC组织,但与性别、年龄、临床分期和组织类型无关;NPC组织中p-eIF4E与p-4EBP1蛋白表达呈正相关,且p-eIF4E和p-4EBP1蛋白阳性的NPC患者生存时间明显短于p-eIF4E和p-4EBP1阴性患者,是NPC判断预后的独立因素。结论 p-eIF4E和p-4EBP1蛋白过表达可能与NPC的发生、发展及不良预后密切相关,p-eIF4E和p-4EBP1有望成为NPC临床诊治和判断预后的分子标志物。Objective To observe the expressions of phosphorylated eukaryotic translation initiation factor 4E （p-eIF4E） and phospho-eIF4E-binding protein I （ p-4EBPI ） and investigate their associations with clinicopathological features and prognosis in nasopharyngeal carcinoma （NPC）. Methods We detected the expressions of p-elF4E and p-4EBP1 proteins by immunohistochemistry in NPC tissues （n = 314 cases）, and analyzed the associations between the expressions of p-eIF4E and p-4EBP1 proteins and cliniospathological features and prognosis in NPC by SPSS16.0. Results Positive rates of p-elF4E and p-4EBP-t proteins in NPC were 74.2% （233/314） and 72. 9% （ 229/314 ）, respectively. There were significantly higher expressions of p-eIF4E and p-4EBP-1 proteins in the cases with lymph node metastasis than in those without lymph node metastasis. However, no significant correlations were observed between the expressions of p-eIF4E and p-4EBP-1 proteins and the age, gender, histological type, and clinical stage. There was significantly positive relationship between p-eIF4E and p-4EBP1 protein expressions in NPC. The overall survival rates were higher in the NPC patients with negative expressions of p-eIF4E and p-4EBP1 proteins than in those with positive expressions. The positive expressions of p-eIF4E and p-4EBP1 proteins were identified as the independent poor prognostic factors in NPC. Conclusion The over-expression of p-eIF4E and p-4EBP-1 proteins may be closely related to the occurrence, development and adverse prognosis of NPC. Hence, p-eIF4E and p-4EBP1 proteins are expected to be molecular markers for clinical diagnosis and prognosis of NPC.

关 键 词：磷酸化的真核细胞翻译起始因子4E(p-eIF4E) 磷酸化的eIF4E结合蛋白1(p-4EBP1) 鼻咽癌(NPC) 

分 类 号：R739.9[医药卫生—肿瘤] R392-33[医药卫生—临床医学]