草酸艾司西酞普兰对老年良性前列腺增生伴抑郁患者的总体疗效  

Effect of escitalopram oxalate on elderly patients with benign prostatic hyperplasia and depression

作　　者：杜文永 施永斌 曹志彬 陈青 郭本玉[3] 季卫东[4] 

机构地区：[1]上海市嘉定区中心医院,上海201800 [2]上海市宝山区中心医院 [3]上海市嘉定区精神卫生中心 [4]上海市长宁区精神卫生中心

出　　处：《国际精神病学杂志》2017年第2期283-286,共4页Journal Of International Psychiatry

摘　　要：目的探讨草酸艾司西酞普兰对老年良性前列腺增生(BPH)伴抑郁患者的总体临床疗效。方法选取104例老年良性前列腺增生合并抑郁症患者,随机分为研究组和对照组,各52例。对照组患者给予常规改善BPH的药物治疗以改善前列腺增生症状,研究组在此基础上给予草酸艾司西酞普兰治疗。比较两组的国际前列腺症状评分(IPSS)、健康调查简表(SF-36)评分和汉密尔顿抑郁量表(HAMD)的评分变化。结果治疗前两组患者上述量表评分组间无明显差异(P>0.05)。治疗后两组患者的IPSS评分均低于治疗前且研究组患者的IPSS评分低于对照组;治疗后研究组HAMD评分显著低于对照组;两组患者治疗后SF-36评分均升高,且观察组高于对照组,上述差异均有统计学意义(P<0.05)。结论老年良性前列腺增生伴抑郁患者在常规改善BPH药物的基础上给予草酸艾司西酞普兰治疗,能够更好地改善其抑郁症状及前列腺增生症状,并能提高患者生活质量。Objective To explore the effect of escitalopram oxalate on elderly patients with benign prostatic hy- perplasia （BPH） and depression. Methods 104 elderly patients with benign prostatic hyperplasia and depression were selected as the research subjects, then divided into the research group and the control group, each group had 52 cases. Patients in the control group were treated with conventional drugs for BPH, and the research group was given escitalo- pram oxalate on this basis. The scores of IPSS, SF-36 scale and HAMD were compared between the two groups. Results There was no significant difference of scores of these scales above between the two groups before treatments （P 〉 0.05 ） . After treatment, the IPSS scores of the two groups were lower than those before treatment, and the IPSS score of the research group was lower than that of the control group; After treatment, the HAMD scores of the research group was significantly lower than that before treatment and that of the control group after treatment; The SF-36 scores of the two groups after treatment were higher than those before treatment, and scores of SF-36 in the research group were higher than those in the control group, all the differences mentioned above were statistically significant （ P 〈 0.05 ） . Con- clusion Escitalopram oxalate drug therapy based on conventional BPH drugs can be better to improve the depressive symptoms and symptoms of benign prostate hyperplasia of elderly benign prostatic hyperplasia patients with depression, and can be better to improve the quality of life of patients as well.

关 键 词：前列腺增生 抑郁 老年 生活质量 

分 类 号：R749.05[医药卫生—神经病学与精神病学]