含不同抗生素四联方案根除幽门螺杆菌的疗效比较  

Effect of different therapies to eradicate Helicobacter Pylori

作　　者：沈晓慧[1,2] 王占伟 宫艺[1] 杜创[1] 李岩[1] 王孟春[1] 

机构地区：[1]中国医科大学附属盛京医院消化内科,沈阳110004 [2]黑龙江省医院消化病院消化二科,哈尔滨150036 [3]解放军沈阳地区医院,沈阳110001

出　　处：《实用药物与临床》2017年第4期390-393,共4页Practical Pharmacy and Clinical Remedies

摘　　要：目的比较临床常用3组幽门螺杆菌(Hp)根除方案(EBAF、EBAC、EBAT)在Hp感染患者中的根除情况、症状缓解情况和成本-效果及不良反应。方法选取我院消化内科门诊Hp感染患者134例,按照数字随机法将Hp感染患者随机分成3组。患者均给予埃索美拉唑、枸橼酸铋钾胶囊、阿莫西林基础治疗,在基础治疗的同时,A组(EBAF)、B组(EBAC)、C组(EBAT)分别添加呋喃唑酮、克拉霉素、替硝唑治疗,疗程为10 d;停药1个月后复查呼气试验。结果 A组的Hp根除率、症状缓解率高于B组、C组,且成本-效果优于B组、C组,差异有统计学意义(P<0.05)。A组的不良反应发生率与B组、C组比较差异无统计学意义(P>0.05)。结论三组根除Hp治疗方案中,EBAF方案的根除率高,成本-效果佳,且不良反应无明显增加,可作为一线方案用于临床根除Hp。Objective To compare the effect of three quadruple therapies of H. pylori （Hp） eradication [esomeprazole-bismuth potassium citrate-amoxicillin-furazolidone （EBAF）, esomeprazole-bismuth potassium citrateamoxicillin-clarithromycin （EBAC） or esomeprazole-bismuth potassium citrate-amoxicillin-tinidazole （EBAT）J in terms of Hp eradication rate, symptom improvement, cost-effectiveness and adverse effects. Methods Totally 134 out- patients with H. pylori infection in our hospital were randomly assigned into 3 groups. All the patients were given es- omeprazole, amoxicillin and bismuth potassium citrate capsules. Group A, group B and group C were also given furazol- idone （ EBAF）, clarithromycin （EBAC） and tinidazole （ EBAT）, respectively, for 10 days. After discontinuation of the treatments for 4 weeks, breath tests were re-performed. Results The rates of lip eradication and symptom improve- ment in group A were higher than those of group B and group C （ P 〈 0.05 ）. There was no significant difference in the incidence of adverse effects among the three groups （ P 〉 0. 05 ）. Conclusion Among the three groups, quadruple therapy with furazolidone shows a higher eradication rate and better cost-effectiveness without an increase in adverse effects. Therefore,it can be recommended as the first-line treatment for clinical eradication of Hp.

关 键 词：HP 呋喃唑酮 阿莫西林 根除率 

分 类 号：R57[医药卫生—消化系统]