综合干预联用网络咨询治疗精神分裂症抑郁症状1年随访  

A follow-up study of comprehensive intervention combined with online consultation in the treatment of depressive symptoms in patients with schizophrenia for one year

作　　者：肖春玲[1] 韩笑乐[1] 张喜梅[1] 陈彦方[1] 邹义壮[1] 郭蓄芳[1] 姚付新[1] 姚长莉[1] 袁秀霞[1] 

机构地区：[1]北京回龙观医院,北京市100096

出　　处：《精神医学杂志》2017年第1期13-16,共4页Journal of Psychiatry

基　　金：美国中华医学基金会(CMB)资助(编号:#02-777);首都临床特色应用研究与成果推广(编号:Z151100004015080)

摘　　要：目的探讨综合干预联用网络咨询治疗社区精神分裂症患者抑郁症状的1年随访结果。方法将106例精神分裂症门诊患者分为研究组(24例有自杀风险症状)和对照组(82例无自杀风险),进行1年的抗精神病药物治疗和综合干预联用网络咨询,在基线时及干预后第1、3、6、12个月末分别采用阳性和阴性综合征量表(PANSS)、社会功能量表(SFRS)和治疗中需处理的不良反应症状量表(TESS)进行评价。结果研究组干预后第1、3、6、12个月末PANSS抑郁症状评分较基线时降低(P>0.05),对照组干预后第6、12个月末PANSS抑郁症状评分较基线时降低(P<0.05);两组干预后第1、3、6、12个月末PANSS总分及阳性症状分、一般病理症状分均较基线时降低(P<0.05),研究组干预后第3、6、12个月末PANSS阴性症状分较基线时降低(P<0.05),对照组治疗后第1、3、6、12个月末PANSS阴性症状分较基线时降低(P<0.05)。对照组干预后第6、12个月末SFRS评分较基线时降低(P<0.05)。两组总不良反应发生率比较差异无统计学意义(P>0.05)。结论综合干预联用网络咨询有利于减轻精神分裂症抑郁症状。Objective To explore the variation of depressive symptoms before and after comprehensive intervention combined with online consultation in patients with schizophrenia for one year. Methods A total of 106 outpatients with schizophrenia were divided into study group （ n = 24 ） with suicide risk and control group （ n = 82 ） without suicide risk and treated with antipsychotics and comprehensive intervention combined with online consultation for one year. They were assessed with Positive and Negative Syndrome Scale （ PANSS ） , Social Functioning Rating Scale （ SFRS ） and Treatment Emergent Symptoms Scale （TESS） at baseline, and at the end of the 1st, 3rd, 6th, 12th month after intervention. Results The factor score of depressive symptoms in PANSS in study group decreased significantly at the end of the 1st, 3rd, 6th ,12th month after intervention compared with the baseline （P 〈 0.05 ） and the factor score in control group decreased significantly at the end of the 6th, 12th month after intervention compared with the baseline （P 〈 0. 05 ）. The total score and factor scores of positive symptoms and general mental pathology in PANSS in both groups decreased significantly at the end of the 1st, 3rd, 6th, 12th month after intervention compared with the baseline （ P 〈 0.05 ）. The factor score of negative symptoms in PANSS in study group decreased significantly at the end of the 3rd, 6th, 12th month after intervention compared with the baseline（ P 〈 0.05 ） and the factor score in control group decreased significantly at the end of the 1st, 3rd, 6th, 12yh month after intervention compared with the baseline （P 〈 0.05）. The score of SFRS in control group decreased significantly at the end of the 6th, 12th month after intervention compared with the baseline （P 〈 0.05 ）. There was no patient committed suicide during the year. There was no difference in total incidence of adverse reactions between two groups （ P 〉 0.05 ）. Conclusion It＇ s helpful for comprehensive inte

关 键 词：精神分裂症 抑郁症状 综合干预 网络咨询 

分 类 号：R749.3[医药卫生—神经病学与精神病学]