Aurora A蛋白在神经母细胞性肿瘤中的表达与其临床特征的关系  

Expression of Aurora A protein in neuroblastic tumors and its relationship with clinical feature

作　　者：罗甜[1,2] 胡群[1] 刘爱国[1] 刘双又[1] 胡迎[1] 张柳青[1] 张艾[1] 王松咪 唐威[1] 丁丽丽[1] 尹萌萌[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院儿童血液科,武汉430030 [2]山东省济宁市第一人民医院,272000

出　　处：《国际输血及血液学杂志》2017年第2期133-136,共4页International Journal of Blood Transfusion and Hematology

摘　　要：目的探讨Aurora A蛋白在神经母细胞性肿瘤（NT）中的表达情况与NT临床特征的关系。方法选择2008年4月至2015年6月于华中科技大学同济医学院附属同济医院就诊的22例NT患儿为研究对象，纳入研究组（n=22）。选择同期于病例收集医院就诊的10例非肿瘤患儿为对照组（n=10）。采用免疫组织化学方法检测Aurora A蛋白在研究组NT患儿肿瘤组织标本和对照组患儿骨髓标本中的表达，并观察Aurora A蛋白表达水平与NT相关临床特征的关系。结果①研究组Aurora A蛋白表达阳性比例为68．2％，显著高于对照组（O），2组比较，差异有统计学意义（P〈O．001）。②研究组中，神经母细胞瘤（NB）和节细胞NB患儿的Aurora A蛋白表达阳性比例比较，差异有统计学意义（P〈0．05），而不同性别、年龄、临床分期、是否发生骨髓转移等患者的Aurora A蛋白表达阳性比例比较，差异无统计学意义（P〉0．05）。结论Aurora A蛋白在NT中呈高表达，其相应的Aurora A激酶抑制剂可能成为治疗NT的新靶向药物。Objective To investigate the expression of Aurora A protein in neuroblastic tumors（NT） and its relationship with clinical features. Methods From April 2008 to June 2015, total of 22 NT patients were collected as study group （n ： 22） from the Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology. Meanwhile 10 none-tumoral patients from the same hospital were included in the study as control group （n： 10）. The expressions of Aurora A protein were detected both in neuroblastic tissues samples of NT patients from study group and in bone marrow samples of non-tumoral patients from control group by technology of immunohistochemistry. The relationship between NT clinical features and the expressions of Aurora A protein were observed. Results ①There were 68.2% of patients were showed with positive expression of Aurora A protein in study group,meanwhile no one showed that in control group, and the differences had statistical significance（P〈0.01）. ②There was significant difference in expression of Aurora A between neuroblastoma（NB） and ganglioneuroblastoma patients in study group（P〈 0.05）. The differences in expression of Aurora A protein between different gender, age, clinical stage and bone marrow transference had no statistical significance（P〉0.05）. Conclusions Aurora A protein is highly expressed in NT, and its corresponding Aurora A kinase inhibitors may be a new target for the treatment of NT.

关 键 词：神经母细胞瘤 预后 AURORA A 

分 类 号：R739.4[医药卫生—肿瘤]