CD147、MUC5ac在周围型非小细胞肺癌中的表达及与CT征象的相关性  

Expressions of CD147 and MUC5ac in peripheral non-small cell lung cancer and their correlationwith CT signs

作　　者：吴强 张祥海 袁海军 

机构地区：[1]宜昌市夷陵医院放射科,湖北省宜昌443100

出　　处：《中国医师杂志》2017年第4期549-551,共3页Journal of Chinese Physician

摘　　要：目的探讨CDl47、MUC5ac在周围型小细胞肺癌中的表达与cT征象的相关性。方法收集42例经手术病理证实、术前行cT检查的周围型非小细胞肺癌患者，对肺癌标本用免疫组化Pv法进行染色检0n,0CD147、MUC5ae的阳性表达，并分析其与CT征象的关系。结果CD147、MUC5ac与周围型非小细胞肺癌的淋巴转移有关（P〈0．05）。CD147的阳性表达与肿瘤的大小、深分叶征、棘突征、纵隔淋巴结肿大有关（P〈0．05），MUC5ac与肿瘤大小、深分叶征、毛刺征、血管集束征、胸膜外脂肪线消失及纵隔淋巴结肿大有关（P〈0．05）。结论CD147、MUC5ac分别在周围型肺癌的侵袭转移过程中发挥重要作用。Objective To investigate the correlation between the expression of CD147 and MUC5ac in peripheral small cell lung cancer and the computed tomography （CT） signs. Methods Forty two cases of peripheral non-small cell lung cancer （NSCLC） confirmed by operation and pathology were examined by CT. The positive expression of CD147 and MUC5ac was detected by immunohistochemical staining and the relationship between the expression of CD147 and MUC5ac was analyzed. Results CD147 and MUC5ae were closely related to the lymphatic metastasis of peripheral non-small cell lung cancer （ P 〈 0. 05 ）. The positive expression of CD147 is significantly related to tumor size, deep lobulation, spinous process and lymphadenopathy （P 〈 0. 05 ）. MUC5ac is significantly related to tumor size, deep lobulation, spiculation, vascular convergence sign, extrapleural fat Line disappearance, and mediastinal lymphadenopathy （ P 〈 0. 05 ）. Conclusions These results indicate that CD147 and MUC5ac play an important role in the inva- sion and metastasis of peripheral lung cancer.

关 键 词：抗原 CDl47/代谢 黏蛋白类/代谢 癌 非小细胞肺/代谢/放射摄影术 体层摄影术 x线计算机 

分 类 号：R734.2[医药卫生—肿瘤]