高分辨多级质谱对吴茱萸次碱及其衍生物的裂解途径的研究  

Research on Fragmentation Pathways of Rutaecarpineand its Derivatives Based on High Resolution Tandem Mass Spectrometry

作　　者：王彬[1,2] 贾正平[1] 马慧萍[1] 王庆[2] 张辉[2] 

机构地区：[1]兰州军区兰州总医院药材科,甘肃兰州730050 [2]湘南学院药学院,湖南郴州423000

出　　处：《湘南学院学报》2017年第2期24-29,共6页Journal of Xiangnan University

摘　　要：应用高分辨多级质谱(ESI-IT-TOF MS)对吴茱萸次碱(1)及其衍生物(2,3)的裂解途径进行了研究.在吴茱萸次碱及其衍生物裂解途径中,CO和HCN基团的消去是其裂解的共同特征;吴茱萸次碱和其衍生物的裂解途径有明显的差异,其衍生物的裂解途径比较相似.我们推测其裂解途径差别是由质子化分子电荷中心的分布的不同造成的.A new method based on electrospray ionization ion-trap time-of-flight tandem mass spectrometry( ESI-IT-TOF MS) was utilized to investigate on the fragmentation pathways of rutaecarpine( 1) and its corresponding derivatives( 2,3). The characteristic elimination,from the precursor protonated ions,of the neutral groups CO and HCN are the common elimination patterns. However,our results further indicated that the fragmentation pathways of rutaecarpine( 1) are obviously different from those of its derivatives( 2,3),while the fragmentation pathways ofcompound2 are similar to that of 3. It is speculated that one possible reason for this difference is the primary positive charge localization in the protonated molecule.

关 键 词：高分辨多级质谱分析 吴茱萸次碱 裂解途径 

分 类 号：TQ464.4[化学工程—制药化工]