依达拉奉联合阿托伐他汀治疗脑梗死的疗效分析  

Effects of edaravone combined with atorvastatin in treatment of cerebral infarction

作　　者：姚涛[1] 湛彦强[1] 胡丹[1] Yao Tao Zhan Yanqiang Hu Dan(Department of Neurolog^^, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, Chin)

机构地区：[1]武汉大学人民医院神经内科,武汉430006

出　　处：《西南国防医药》2017年第5期454-456,共3页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的探讨依达拉奉与阿托伐他汀联合治疗脑梗死的临床疗效及安全性。方法将医院收治的92例脑梗死患者随机分为对照组(45例)和联合组(47例),在常规治疗基础上,对照组加用阿托伐他汀治疗,联合组采用依达拉奉与阿托伐他汀联合治疗。比较两组治疗前后血脂水平、临床疗效、美国国立卫生研究院卒中量表(NIHSS)评分的变化。治疗结束后随访6个月,统计不良反应发生率、复发率和病死率。结果治疗后两组血脂水平均显著下降,NIHSS评分减少(P<0.05),两组间血脂水平无统计学差异(P>0.05),但联合组NIHSS评分显著低于对照组(P<0.05);联合组总有效率为80.9%,较对照组(62.2%)显著提高(P<0.05)。随访期间,对照组复发率(26.7%)显著高于联合组(10.6%)(P<0.05),两组均无死亡病例。两药联合使用未增加患者不良反应的发生率。结论依达拉奉联合阿托伐他汀治疗能显著促进脑梗死患者神经功能恢复,降低复发率,且不良反应发生率低。Objective To explore the effects and safety of edaravone combined with atorvastatin in the treatment of cerebral infarction. MeAods A total of 92 patients with cerebral infarction admitted to our hospital were selected and randomly divided into a control group （n = 45） and a combination group （n = 47）. On the basis of conventional treatment, the control group was additionally treated with atorvastatin and the combination group with edaravone combined with atorvastatin. The changes in the blood lipid level, clinical efficacy and NIHSS before and after the treatment between the two groups were compared. During the six-month follow-up visit after the treatment, the incidence of adverse reactions, recurrence rate and death rate were recorded. Results The post-treatment blood lipid level in the two groups decreased greatly, NIHSS decreased, too （P 〈 0.05）; there was no significant difference in the blood lipid level between the two groups （P 〉 0.05）; the NIHSS in the combination group was significantly lower than that in the control group （P 〈 0.05）; the ORR in the combination group was 80.9%, which was significantly higher than that （62.2%） in the control group （P〈 0.05）. During the follow-up visit, the recurrence rate（26.7%） in the control group was significantly higher than that （10.6%） in the combination group （P 〈 0.05）. There was no death in the two groups. The combination with the two drugs did not increase the incidence of adverse reactions. Conclusion Edaravone combined with atorvastatin can significantly promote the recovery of neurological function in patients with cerebral infarction, and lower the recurrence rate and the incidence of adverse reactions.

关 键 词：脑梗死 依达拉奉 阿托伐他汀 疗效 

分 类 号：R743.33[医药卫生—神经病学与精神病学]