阿尔茨海默症炎症反应及中药干预研究进展  

Research progress on inflammation of Alzheimer's disease and intervention of traditional Chinese medicine

作　　者：梁跃霞 曹国琼[1,2,3] 张文生[1,2,3] LIANG Yue- xia CAO Guo-qiong ZHANG Wen-sheng(Beijing Area Major Laboratory of Protection and Utilization of Traditional Chiness Medicine, Beijing Normal University, Beijing 100088 , China Engineering Research Center of Natural Medicine,Ministry of Edgatiop,Beijing Normal University,Beijing 100088 , China College of Resources Science Technology ,Beijing Normal University ,Beijing 100875 , China)

机构地区：[1]北京师范大学中药资源保护与利用北京市重点实验室,北京100088 [2]教育部天然药物工程研究中心,北京100088 [3]北京师范大学资源学院,北京100875

出　　处：《中国药理学通报》2017年第5期597-602,共6页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81274118);国家科技部"重大新药创制"科技重大专项资助项目(No2012ZX09103-201);中央高校基本科研业务费项目(No2015KJJCA05)

摘　　要：炎症反应贯穿于阿尔茨海默症病理过程。以Aβ为核心的老年斑周围聚集着大量激活态小胶质细胞。Aβ通过小胶质细胞的Aβ受体产生NO、ROS及促炎细胞因子TNF-α、IL-1β、IL-6等神经毒性分子。该文对小胶质细胞表达的Aβ受体引起慢性炎症机制进行综述,并对以这些Aβ受体为作用靶点的中药有效成分做一总结。Inflammation plays an important role in the Alzheimer＇s disease, with a large number of activated microglia gathered around the core of amyloid beta（Aβ）plaque.The interaction of Aβ with Aβ receptors of microglia can directly stimulate the microglia to produce neurotoxic molecules, such as NO, ROS, pro-inflammatory cytokines TNF-α, IL-6, IL-1β,which induces chronic inflammation in the brain.The mechanism of chronic inflammation resulted from microglia Aβ receptors in the brain is overviewed, and traditional Chinese medicine ingredients which target these Aβ receptors to defend inflammation in the central nervous system is summarized.

关 键 词：阿尔茨海默症 炎症反应 小胶质细胞 Aβ受体 Β淀粉样蛋白 晚期糖基化终末产物受体 

分 类 号：R-05[医药卫生] R329.24