“固本解毒祛瘀”方药联合化疗治疗晚期非小细胞肺癌疗效观察  

Effect of Guben Jiedu Quyu prescription with chemotherapy on the NSCLC

作　　者：张富亮[1] 孔凡铭[2] 李冬生[1] 胡国华[1] 徐桐柏[1] 乔曼[1] 陈艳华[1] 迟航[1] ZHANG Fu-liang KONG Fan-ming LI Dong-sheng HU Guo-hua XU Tong-bai QIAO Man CHEN Yan-hua CHI Hang(l.Tianjin Nankai Hospital, Tianjin 300100, China First TeachingHospital ofTianjin University ofTraditional Chinese Medicine,Tianjin 300193, China)

机构地区：[1]天津市南开医院,天津300100 [2]天津市中医药大学第一附属医院,天津300193

出　　处：《天津中医药》2017年第5期320-322,共3页Tianjin Journal of Traditional Chinese Medicine

基　　金：天津市中医药管理局项目(2015027);国家青年科学自然基金项目(81403220)

摘　　要：[目的]观察"固本解毒祛瘀"方药联合化疗治疗非小细胞肺癌(NSCLC)患者疗效观察。[方法]将80例非小细胞肺癌患者随机分为两组,对照组40例采用单纯化疗加对症治疗,治疗组40例在对照组基础上加用"固本解毒祛瘀"方药治疗,比较两组外周血常规、血T淋巴细胞亚群及卡氏(KPS)评分。[结果]与治疗前相比较,治疗组与对照组血WBC、HGB和PLT均减低(P<0.05),而对照组减低更明显(P>0.05);与治疗前比较,治疗组在CD3^+、CD4^+、CD4^+/CD8^+较治疗前明显上升,有显著差异(P<0.01),而对照组治疗后CD3^+水平下降,与治疗前比较,有显著性差异(P<0.05);KPS评分治疗组治疗前后组内比较,差异有统计学意义(P<0.05)。[结论]"固本解毒祛瘀"方药可以减轻晚期NSCLC化疗患者骨髓抑制,增强免疫功能及改善生存质量。[Objective] To investigate the effect of Guben Jiedu Quyu prescription with chemotherapy on the non-small cell lung cancer （NSCLC）. [Methods ] Total of 80 NSCLC patients who received treatment were enrolled. The patients were divided into two groups based on the treatment. Forty patients in control group were received chemotherapy and forty patients in treatment group were received chemotherapy and Guben Jiedu Quyu prescription. The blood routine examination, peripheral blood Tlymphocyte subsets, and Karnofsky Performance Scores （KPS） were compared between two groups. [Results] The blood WBC,HGB and PLT were significantly decreased in the treatment group and the control group after treatment （P〈0.05）,While the control group was more significantly decreased than the treatment group （P〉0.05）. Forthe peripheral blood T lymphocyte subsets,the CD3＋、 CD4＋、 CD4＋/CD8＋were all increased in the treatment group （P〈0.01）,while the CD3＋ was decreased in the control group （P〈0.05）. The KPS was also improved in the experiment group （P〈0.05）. [Conclusion] Guben Jiedu Quyu prescription can reduce bone marrow suppression of chemotherapy,enhance immune function and improve the quality of life ofNSCLC patients.

关 键 词：固本解毒祛瘀 非小细胞肺癌 疗效 

分 类 号：R734.2[医药卫生—肿瘤]