上皮性卵巢癌组织中FOXC1的表达变化及意义  

Expression changes and significance of FOXC1 in human epithelial ovarian cancer

作　　者：黄玲[1] 任琛琛[1] 杨立[1] 白杨[1] 薛景戈 刘灵[1] 李倩[1] 

机构地区：[1]郑州大学第三附属医院,郑州450052

出　　处：《山东医药》2017年第13期13-16,共4页Shandong Medical Journal

基　　金：河南省科技厅科技攻关项目(162102310131);河南省科技厅科技攻关项目(142300410205)

摘　　要：目的探讨上皮性卵巢癌组织中叉头框蛋白C1(FOXC1)的表达变化及意义。方法选取良性上皮性卵巢瘤30例份、交界性上皮性卵巢瘤30例份、上皮性卵巢癌70例份,应用免疫组化SP法检测组织FOXC1、上皮性黏钙蛋白(E-cadherin)、波形蛋白(Vimentin)表达水平,比较其三者与临床病理参数的关系;随访患者3年,比较组织中FOXC1、E-cadherin和Vimentin表达阳性与阴性患者的3年累积生存率。结果 (1)与良性上皮性卵巢瘤组织比较,上皮性卵巢癌组织中FOXC1、E-cadherin表达阳性率降低,Vimentin表达阳性率升高(P均<0.05)。(2)FOXC1阳性表达的卵巢癌组织中E-cadherin表达阳性率为28.6%(20/70)、Vimentin表达阳性率为15.7%(11/70),FOXC1表达与Ecadherin表达呈正相关(r=0.446,P=0.000),与Vimentin表达呈负相关(r=-0.295,P=0.014)。(3)上皮性卵巢癌组织中FOXC1蛋白表达与淋巴结转移、二元论分型、两组分级有关,E-cadherin、Vimentin蛋白表达与淋巴结转移、临床分期、二元论分型、两级分级有关(P均<0.05)。(4)上皮性卵巢癌组织中FOXC1、E-cadherin阳性患者3年累积生存率分别为82.1%、80.6%,高于FOXC1、E-cadherin阴性患者69.0%、69.2%,Vimemtin阳性患者3年累积生存率为70%,低于Vimemtin阴性患者80%(P均<0.05)。结论上皮性卵巢癌组织中FOXC1的表达降低,其表达缺失介导了卵巢的上皮间质转化,可能参与了卵巢癌的发生发展,并可评估其预后。To investigate the expression changes and significance of fork box protein C1 （FOXC1） in human epithelial ovarian cancer （EOC）.Methods The expression of FOXC1, E-cadherin and Vimentin in 30 cases of benign EOC tissues, 30 cases of borderline ECO tissues and 70 cases of ECO tissues was detected by immunohistochemical SP staining.The ovarian cancer patients were followed up for 3 years, and the 3-year cumulative survival rate was compared between ovarian cancer patients with positive and negative FOXC1, E-cadherin and Vimentin.Results ①The positive expression rates of FOXC1 and E-cadherin in the borderline ECO tissues were decreased, and the positive expression rate of Vimentin was increased as compared with those of the benigh ECO tissues （P〈0.05）.② The positive expression rate of E-cadherin was 28.6% （20/70）, the positive expression rate of Vimentin was 15.7% （11/70） in ovarian cancer tissues with positive expression of FOXC1, the expression of FOXC1 was positively correlated with the expression of E-cadherin （r=0.446, P=0.000）, and was correlated with Vimentin expression （r=-0.295, P=0.014）.③ The expression of FOXC1 protein in EOC tissues was negatively correlated with lymph node metastasis, dualistic type and grading, and the protein expression of E-cadherin and Vimentin was correlated with lymph node metastasis, clinical classification, dualistic type and grading （all P〈0.05）.④The 3-year cumulative survival rates of EOC patients with positive expression of FOXC1 and E-cadherin was 82.1% and 80.6%, respectively, which were higher than those in patients with negative expression of FOXC1 and E-cadherin （69.0% and 69.2%）.The 3-year cumulative survival rates of EOC patients with positive expression of Vimentin was 70%, which was significantly lower than that in patients with negative Vimentin （80%） （all P〈0.05）.Conclusions The expression of FOXC1 is decreased in ovarian cancer tissues, and the loss expression of FOXC1 may be a role in the process of EMT.Mean

关 键 词：上皮性卵巢癌 叉头框蛋白C1 上皮间质转化 上皮性黏钙蛋白 波形蛋白 

分 类 号：R737.31[医药卫生—肿瘤]