结肠癌根治术后5年无病生存率影响因素分析  

Predictors of disease-free survival after radical resection of colon cancer for 5 years

作　　者：刘清华[1] 陈依红[2] 

机构地区：[1]梅州市人民医院病理科,广东梅州514031 [2]梅州市人民医院信息科,广东梅州514031

出　　处：《结直肠肛门外科》2017年第1期27-31,共5页Journal of Colorectal & Anal Surgery

摘　　要：目的研究结肠癌根治术后患者5年无病生存率影响因素。方法纳入548例接受结肠癌根治术患者作为研究对象,随访记录5年无病生存率,采用COX模型探讨影响5年无病生存率的影响因素,并对有预测价值的因素做受试者工作特征曲线(ROC),分析其准确性。结果经COX模型分析发现TNM分期、CEA及淋巴结和远处转移是影响患者术后5年无病生存率的独立因素(P<0.05)。CEA对患者5年无病生存率预测价值的ROC曲线显示,其曲线下面积(AUC)为0.866,敏感度为0.994,特异度为0.783。结论 TNM分期、CEA水平及淋巴结和远处转移是影响结肠癌根治术后5年无病生存率的高危因素,CEA水平对预测术后患者5年无病生存率有较高的应用价值。Objective To study the predictors of 5-yar disease-free survival after radical resection of colon cancer. Methods 548 patients undergoing radical resection of colon cancer were selected as subjects. The 5-year disease-free survival were recorded and the COX multivariate analysis was used to investigate the influencing factors of disease-free survival in 5 years The receiver operating characteristic curve was used to calculate sensitivity and specificity. Results The COX multivariate analysisn showed that TNM stage,CEA and lymph node and distant metastasis were independent factors affecting disease-free survival in 5 years after operation（P〈 0.05）. The ROC curve of CEA for predicting the 5-year disease-free survival showed that the area under the curve（AUC）,sensitivity and specificity were 0.866,0.994 and 0.783,respectively. Conclusion The TNM staging,CEA level,lymph node and distant metastasis are the predictors of 5-year disease-free survival after radical resection of colon cancer. CEA level has a high value to predict the 5-year disease-free survival rate.

关 键 词：结肠癌 5年无病生存率 影响因素 

分 类 号：R735.35[医药卫生—肿瘤]