Cyr61、VEGF在结直肠癌组织中的表达及其临床病理意义  

Expression of Cyr61 and VEGF in the colorectal cancer and its clinical significance

作　　者：方亮[1] 王昌权[1] 陈颖[1] 吴继雄[1] 曹钟[2] FANG Liang WANG Chan- gquan CHEN Ying WU Jixiong CAO Zhong(Department of Gastroenterology,Huanggang Central Hospital,Hubei Province, Huanggang 438000, Chin)

机构地区：[1]湖北省黄冈市中心医院消化内科,438000 [2]湖北省黄冈市中心医院病理科,438000

出　　处：《疑难病杂志》2017年第5期481-484,I0001,共5页Chinese Journal of Difficult and Complicated Cases

摘　　要：目的探讨富半胱氨酸蛋白-61(Cyr61)、血管内皮生长因子(VEGF)在结直肠癌中的表达水平和临床意义。方法选取2011年1月—2014年1月黄冈市中心医院收治的结直肠癌患者94例作为结直肠癌组,结肠炎患者20例作为结肠炎组,手术切除的标本应用免疫组化法检测Cyr61、VEGF的表达情况,分析Cyr61、VEGF蛋白表达与临床病理关系,随访患者存活率,并分析Cyr61、VEGF与患者预后关系。结果结直肠癌组组织中Cyr61和VEGF相对表达量与结肠炎组比较差异有统计学意义(Z=-2.647、-3.154,P<0.01)。结直肠癌组中肿瘤中高分化程度患者Cyr61和VEGF高表达率与低分化程度患者比较差异有统计学意义(x^2=8.309、7.733,P<0.01);肿瘤浸润T3/T4患者Cyr61和VEGF高表达率与T1/T2患者比较差异有统计学意义(x^2=4.532、3.778,P<0.05);有淋巴转移患者Cyr61和VEGF高表达率与无淋巴转移患者比较差异有统计学意义(x^2=6.365、7.050,P<0.01);Ⅲ+Ⅳ患者Cyr61和VEGF高表达率与Ⅰ+Ⅱ患者比较差异有统计学意义(x^2=34.535、57.343,P<0.01)。Cyr61高表达患者平均生存时间与Cyr61低表达患者比较差异有统计学意义(t=32.80,P<0.01);VEGF高表达患者平均生存时间与VEGF低表达患者比较差异有统计学意义(t=19.13,P<0.01)。多因素回归分析结果显示,VEGF表达水平、Cyr61表达水平是患者预后的独立危险因素。结论直结肠癌组织中,Cry61和VEGF与肿瘤的分化程度、浸润与否、淋巴转移和TNM分期密切相关。在临床中可通过检测Cry61和VEGF水平,对直结肠癌进行早期诊断、判断直结肠癌预后。Objective To investigate the expression and clinical significance of Cyr61 and VECF in the development of colorectal cancer.Methods Ninety-four cases of colorectal cancer patients who were treated in our hospital were selected as colorectal cancer group,and 20 cases of colitis patients enrolled as control group.Detected Cyr61 and VECF by immunohistochemical method,analyzed the relationship between the expression Cyr61,VEGF protein and the clinical pathological,the survival rate of patients with follow-up.Results The relative expression of Cyn61 and VEGF in the normal group was significantly lower than those in the colorectal cancer group（P 〈0.01）;High expression rates,of Cyr61 and VEGF were significantly lower in the patients with middle and high differentiation than those with low degree of differentiation（x2 = 8.309,x2 =7.733,P 〈0.01）;T3/T4 patients CynSl and VEGF expression was significantly higher than that in T1/T2 patients（x2=4.532,x2=3.778,P 〈0.05）;lymph node metastasis of CynSl and VEGF in patients with high expression rate was significantly higher than that without lymph node metastasis（x2=6.365,x2=7.050,P 〈 0.01）;Ⅲ and Ⅳ patients Cyr61 and VEGF high expression rate was significantly higher than that of the Ⅰ＋Ⅱ patients（x2=34.535,x2=57.343,P 〈0.01）;the average survival time of patients with high expression of CynSl was significantly lower than patients with low CYR61 expression（t =32.80,P 〈0.01）;the average survival time of patients with high expression of VECF was significantly lower than patients with low VEGF expression（t = 19.13,P 〈0.01）.Conclusion In colorectal cancer,the VEGF and Cry61 were closely related to the degree of tumor differentiation,infiltration,lymph node metastasis and TNM stage.In clinic,Cry61 and VEGF levels can be detected for the early diagnosis of colorectal cancer and the prognosis of colorectal cancer.

关 键 词：结直肠癌 富含半胱氨酸蛋白-61 血管内皮生长因子 临床病理 

分 类 号：R735.34[医药卫生—肿瘤]