钠钾镁钙葡萄糖注射液补液量与鼻咽癌同步放化疗患者癌因性疲乏、抑郁情绪及耐受性的相关性  

Effects of Natrium Kalium Magnesium Calcium Glucose Injection Fluid Replacement on Cancer-related Fatigue and Emotion and Tolerance of Tumor Chemotherapy Patients

作　　者：罗维[1] 李娟[1] 吴艳[1] 王帅[1] 杨镇洲[1] LUO Wei LIJuan WU Yan WANG Shuai YANG Zhen-zhou(Cancer Center, The Third Affiliated Hospital of the Third Military Medical University, Chongqing 400042, Chin)

机构地区：[1]第三军医大学第三附属医院肿瘤中心,重庆400042

出　　处：《中国医药指南》2017年第10期1-3,共3页Guide of China Medicine

基　　金：CSCO自然基金资助;项目号:Y-MT2015-015

摘　　要：目的探讨钠钾镁钙葡萄糖注射液补液量对鼻咽癌同步放化疗患者癌因性疲乏、抑郁情绪及耐受性的影响。方法选择我院2012年6月至2015年8月收治的鼻咽癌患者90例作为研究对象,根据随机数字表将入选患者分为观察组(n=47)与对照组(n=43)。两组鼻咽癌患者均同步每周1次顺铂化疗,共7周,顺铂化疗当日补液量均为2500 m L,其中观察组含钠钾镁钙葡萄糖注射液1000 m L,对照组则为常规5%葡萄糖氯化钠注射液。比较两组患者癌因性疲乏(应用CFS量表评估)、抑郁情绪(用SDS量表评估)、耐受性及生活质量(应用QLQ-C30量表评估)。结果观察组化疗1、3、5、7周时的CFS评分均低于对照组,化疗5周及7周时观察组SDS评分均低于对照组,差异有统计学意义(P<0.05)。观察组化疗总中断率为4.3%,低于对照组20.9%,差异有统计学意义(P<0.05)。观察组出院时的功能量表总分与总体健康状况评分均高于对照组,症状量表总分与单项条目总分低于对照组,差异有统计学意义(P<0.05)。结论鼻咽癌同步顺铂化疗进行治疗患者化疗期间补充钠钾镁钙葡萄糖注射液可最大限度改善患者对肿瘤化疗患者癌因性疲乏、抑郁情绪,提高患者耐受性,临床价值显著。Objective To explore effects of natrium kalium magnesium calcium glucose injection fluid replacement on cancer-related fatigue and emotion and tolerance of tumor chemotherapy patients. Methods 90 patients with nasopharyngeal carcinoma in our hospital from June 2012 to August 2015 were selected as the research objects, they were divided by random number table into the observation group（n=47） and the control group（n=43）. Both groups received cisplatin-based synchronous chemotherapy once a week during the 7 weeks radiotherapy. The total infusion volume was 2500 m L at the day of cisplatin administration. Among them 1000 m L of natrium-kalium-magnesium-calcium and glucose injection（NKMCG injection） was distributed for observation group, while normal glucose injection was distributed for control group. Cancer-related fatigue（estimated by CFS scale）, depression（estimated by SDS scale）, tolerance and quality of life（estimated by QLQ-C30 scale） were compared between two groups. Results CFS scores of the observation group at 1, 3, 5, 7 weeks of chemotherapy were significantly lower than the control group, at 5, 7 weeks of chemotherapy, SDS scores of the observation group were significantly lower than the control group（P〈0.05）. Chemotherapy total outage rate in the observation group was 4.3%, which was significantly lower than the control group（20.9%）（P〈0.05）. Functional scale total scores and total health status scores in the observation group at discharge were significantly higher than the control group, symptom scale total scores and single item total scores were significantly lower than the control group（P〈0.05）. Conclusion2500 m L natrium kalium magnesium calcium glucose injection add to patients with nasopharyngeal carcinoma treated by cisplatin-based chemotherapy can improve cancer-related fatigue, depression of tumor chemotherapy patients to the utmost, improve patients＇ tolerance with significant clinical value.

关 键 词：鼻咽癌 癌因性疲乏 情绪 耐受性钠钾镁钙葡萄糖注射液 

分 类 号：R739.63[医药卫生—肿瘤]