瘢痕疙瘩发病机制的研究  

Progress in the Pathogenesis of Keloids

作　　者：朱莲花[1] 李美玲[1] 李周娜[1] 金哲虎[1] 

机构地区：[1]延边大学附属医院皮肤科,吉林延吉133000

出　　处：《中国皮肤性病学杂志》2017年第5期560-562,共3页The Chinese Journal of Dermatovenereology

基　　金：国家自然科学基金项目(81060233);吉林省教育厅"十二五"科学技术研究项目【吉教科合字(2012)第2号】;吉林省产业技术研究与开发项目(2013 C034);吉林省卫生厅项目(2014Z094)

摘　　要：瘢痕疙瘩是一种以侵袭性生长为特点的良性肿瘤。瘢痕疙瘩有一定的遗传易感性,瘢痕疙瘩患者多有家族倾向性及家族聚集性,属于常染色体显性遗传。皮肤创伤愈合过程中受多种细胞因子,信号传导通路,细胞外基质的影响下,成纤维细胞的过度增殖和细胞外基质中胶原的沉积而导致瘢痕疙瘩的形成。近年来,很多学者通过分子生物学研究得出瘢痕疙瘩形成过程中各种基因作用机制及细胞因子的表达异常,对瘢痕疙瘩的诊断及治疗提供了一个新方向。Keloid is a benign tumor with characteristics of aggressive growthPatients with keloid have familial tendency and aggregation due to genetic predisposition to keloid, the autosomal dominant inheritanceDuring the process of skin wound healing, cytokines together with multiple signaling pathway and extracellular matrix provoke hyperproliferation of fibroblasts and excessive deposition of collagen in the extracellular matrix, leading to the formation of keloidRecently through molecular biology research scientists have revealed the mechanisms of genetic effects and abnormal expression of cytokines during the formation of keloid, leading to a new direction for the diagnosis and treatment of keloid.

关 键 词：瘢痕疙瘩 发病机制 基因 细胞因子 

分 类 号：R739.5[医药卫生—肿瘤]