发热感染相关性癫痫综合征一例  

A case of febrile infection related epilepsy syndrome

作　　者：薛红[1] 吕艳[2] 韩桐师[1] 薛霞[1] 潘树义[2] 

机构地区：[1]空军航空医学研究所附属医院高压氧科,北京100089 [2]海军总医院

出　　处：《脑与神经疾病杂志》2017年第5期310-314,共5页Journal of Brain and Nervous Diseases

摘　　要：目的总结发热感染相关性癫痫综合征(FIRES)的诊疗过程,并复习相关文献,以供临床工作者借鉴。方法复习本科确诊的1例FIRES患者的病例,参照相关文献,就该病的临床特征、诊疗经过、治疗方法、预后进行分析。结果 FIRES是一种病因不明,以难治性癫痫为主要临床表现,伴随发热、感染的疾病。常见于既往智体健康的儿童,癫痫发作不易缓解,且对各类抗癫痫药物耐受,生酮饮食部分有效;辅助检查无特异性指标,预后不良。结论 FIRES国内外病例报道较少,诊疗经验欠缺,需继续总结。Objective To review the medical records of febrile infection related epilepsy syndrome, febrile infection relatedepilepsy syndrome （ FIRES ） and provide the reference for the clinician. Method We analyzed the clinical features, diagnosis, treatment and prognosis of a patient with FIRES in our department and reviewed all related literatures. Results FIRES is a rare childhood epileptic syndrome. It is characterized by the occurrence of refractory status epileptic during or after fever and inflammation. It presents with multifocal refractory status epilepticus in previously normal children and evolves into a chronic, refractory, focal epilepsy with associated cognitive and behavioral difficulties. Markers in cerebral fluid and blood are few. It is partly responsive to ketogenic diet.Conclusion There are few literatures here and abroad. We know little about its diagnosis and treatment. More attention are paid to it.

关 键 词：发热 癫痫 诊断 

分 类 号：R742.1[医药卫生—神经病学与精神病学]