Efficacy of a traditional Persian medicine preparation for radiation-induced xerostomia:a randomized,open-label,active-controlled trial  

作　　者：Ghazaleh Heydarirad Hossein Rezaeizadeh Rasool Choopani Seyed Hamdollah Mosavat Ahmad Ameri 

机构地区：[1]Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran 15167-45811, Iran [2]Department of Traditional Medicine, School of Traditional Medicine, Tehran University of Medical Science, Tehran 16687-53961, Iran [3]Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences,Shiraz 71356-44144, Iran [4]Essence of Parsiyan Wisdom Institute, Traditional Medicine and Medicinal Plant Incubator, Shiraz University of Medical Sciences, Shiraz 71356-44144, Iran [5]Department of Radiation Oncology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences,Tehran 19946-15611, Iran

出　　处：《Journal of Integrative Medicine》2017年第3期201-208,共8页结合医学学报（英文版）

摘　　要：BACKGROUND： Xerostomia is one of the most common side effects of radiation therapy among patients with head and neck cancers （HNC）. However, conventional medicine lacks an effective treatment for radiation-induced xerostomia. OBJECTIVE： Synthesizing the traditional use ofAIcea digitata and Malva sylvestris with their known beneficial effects from recent studies, we evaluated the efficacy of the herbs in the quality of life （QOL） of HNC patients with radiation-induced xerostomia. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS： This study is a randomized, double-arm, open-label active-controlled clinical trial. We evaluated the effect ofA. digitata and M. sy/vestris on QOL of HNC patients with radiation-induced xerostomia compared with Hypozalix （artificial saliva）. Patients were enrolled from the Imam Hossein Hospital＇s oncology clinic in Shahid Beheshti University of Medica Sciences. Tehran, Iran. MAIN OUTCOME MEASURES： Primary outcome measures in this trial were changes in patients＇ QOL assessed by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, Head and Neck Module （EORTC QLQ-H＆N 35）. RESULTS： Between-group analysis showed that the intervention group patients obtained significantly lower （better） total EORTC QLQ-H＆N 35 scores as compared to the control group at the end of the intervention period （P = 0.007）. Mean scores of dry mouth of EORTC QLQ-H＆N 35 was also significantly lower （better） in the intervention group as compared to the control group （P = 0.017）.BACKGROUND： Xerostomia is one of the most common side effects of radiation therapy among patients with head and neck cancers （HNC）. However, conventional medicine lacks an effective treatment for radiation-induced xerostomia. OBJECTIVE： Synthesizing the traditional use ofAIcea digitata and Malva sylvestris with their known beneficial effects from recent studies, we evaluated the efficacy of the herbs in the quality of life （QOL） of HNC patients with radiation-induced xerostomia. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS： This study is a randomized, double-arm, open-label active-controlled clinical trial. We evaluated the effect ofA. digitata and M. sy/vestris on QOL of HNC patients with radiation-induced xerostomia compared with Hypozalix （artificial saliva）. Patients were enrolled from the Imam Hossein Hospital＇s oncology clinic in Shahid Beheshti University of Medica Sciences. Tehran, Iran. MAIN OUTCOME MEASURES： Primary outcome measures in this trial were changes in patients＇ QOL assessed by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, Head and Neck Module （EORTC QLQ-H＆N 35）. RESULTS： Between-group analysis showed that the intervention group patients obtained significantly lower （better） total EORTC QLQ-H＆N 35 scores as compared to the control group at the end of the intervention period （P = 0.007）. Mean scores of dry mouth of EORTC QLQ-H＆N 35 was also significantly lower （better） in the intervention group as compared to the control group （P = 0.017）.

关 键 词：XEROSTOMIA MEDICINE Persian traditional hollyhocks common mallow cancer 

分 类 号：R730.55[医药卫生—肿瘤]