力学因素对细胞自噬的影响  

Effects of mechanical factors on autophagy

作　　者：桂金鹏 江静怡 张灵玉 纳静[1] 樊瑜波[1] 郑丽沙[1] 

机构地区：[1]北京航空航天大学生物与医学工程学院,生物力学与力生物学教育部重点实验室,北京市100191

出　　处：《中国组织工程研究》2017年第12期1946-1952,共7页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(11572030)~~

摘　　要：背景:心肌肥大、椎间盘退行性疾病等疾病的发生与其组织细胞所处力学环境密切相关,而自噬在这些疾病的发病过程起到重要作用。目的:综述力学因素对不同组织细胞自噬的影响及其涉及的分子机制,为自噬的研究及相关疾病的预防治疗提供参考作用。方法:检索2000至2016年Web of Science和Pub Med数据库中关于力学因素对细胞自噬影响的文献,英文检索词为"autophagy,mechanical",进行系统的归纳总结和分析,排除内容相关性差或重复文献,最终得到52篇文献。结果与结论:(1)力学因素对心肌细胞、内皮细胞、软骨细胞、骨骼肌细胞等多种细胞的自噬产生影响,细胞自噬是细胞应对刺激的一种自我保护性反应,在受到生理水平的力学刺激时,细胞上调自噬水平,维持细胞的稳态、功能以及存活;(2)力学因素可能通过PI3K-AKT-mTOR、氧自由基、AKT-FoxO等通路引起细胞自噬,具体机制有待进一步研究。BACKGROUND：Numerous diseases like cardiac hypertrophy and intervertebral disc degeneration are known to be implicated in the changes of mechanical stress acting on surrounding tissues or cells, and autophagy contributes to the pathogenesis of these diseases. OBJECTIVE：To review the effects of mechanical factors on autophagy in different tissues and the underlying molecular mechanisms, thereby providing references for the research of autophagy and the prevention and treatment of related diseases. METHODS：A search of Web of Science and PubMed databases was performed for the literatures addressing the effects of mechanical factors on autophagy using the English keywords of＂autophagy, mechanical＂and the articles were summarized systematically. Finally, 52 literatures were enrolled according to the inclusion and exclusion criteria. RESULTS AND CONCLUSION：Mechanical factors make great effects on autophagy of various cells, such as myocardial cells, endothelial cells, chondrocytes and skeletal muscle cells. Autophagy is a self-protective reaction, and the mechanical stress of physiological conditions induces autophagy to maintain cell homeostasis, normal function and survival. The mechanism of autophagy induced by mechanical stress may involve PI3K-AKT-mTOR, oxygen free radical, AKT-FoxO and other pathways, and the definite mechanism needs to be further studied.

关 键 词：组织构建 组织工程 细胞自噬 力学因素 心肌细胞 软骨细胞 内皮细胞 心肌肥大 椎间盘退行性疾病 国家自然科学基金 

分 类 号：R394.2[医药卫生—医学遗传学]