阿立哌唑对抗精神病药物所致高泌乳素血症的影响  

Effects of aripiprazole on the antipsychotic-induced hyperprolactinemia

作　　者：汪正华[1] 阚博[1] 周恒[1] 

机构地区：[1]芜湖市第四人民医院精神科,安徽芜湖241000

出　　处：《皖南医学院学报》2017年第2期143-145,共3页Journal of Wannan Medical College

摘　　要：目的:探讨阿立哌唑对抗精神病药物所引起的高泌乳素血症的影响。方法:将90例抗精神病药物所致高泌乳素血症患者随机分为3组,实验组一30例(阿立哌唑5 mg/d),实验组二30例(阿立哌唑10 mg/d),对照组30例未添加阿立哌唑治疗,治疗8周。分别于基线期、4周后、8周后监测血清泌乳素水平,于基线期及8周后采用PANSS量表评估疗效,TESS评估药物不良反应。结果:(1)实验组治疗前后泌乳素水平存在统计学差异(P<0.05);(2)实验组一和实验组二治疗后泌乳素水平无统计学差异(P>0.05),对照组治疗前后泌乳素水平无统计学差异(P>0.05);(3)实验组组间治疗后PANSS量表、TESS量表无统计学差异(P>0.05)。结论:阿立哌唑能够改善抗精神病药物所引起的高泌乳素血症,且不存在量效关系。Objective：To observe the effect of aripiprazole on hyperprolactinemia induced by antipsychotics.Methods：Ninety patients with hyperprolactinemia induced by antipsychotics were randomized into study group 1（aripiprazole 5 mg/day,n=30）,study group 2（aripiprazole 10 mg/day,n=30）,and control group（free from aripiprazole,n=30）.Therapy duration was 8 weeks.Plasma prolactin levels were measured respectively at the baseline,4 and 8 weeks after medication.Positive and Negative Symptom Scale（PANSS） was used to evaluate the therapeutic effect,and Treatment Emergent Symptom Scale（TESS） to assess the adverse effect at the baseline and 8 weeks after therapy.Results：①Plasma prolactin level was significantly different in the two study groups before and after therapy（P〈0.05）;②There was no statistical difference between study group 1 and 2 regarding the plasma prolactin level following therapy（P〉0.05）,and the difference was not significant in the control group before and after therapy（P〉0.05）;③Scoring on the PANSS and TESS was not significant within and between study groups（P〉0.05）.Conclusion：Aripiprazole is effective to hyperprolactinemia induced by antipsychotics,and has dose-effect relation in therapy regimen.

关 键 词：阿立哌唑 泌乳素 精神分裂症 

分 类 号：R749.3[医药卫生—神经病学与精神病学]