CEACAM1和CD34蛋白表达与胃癌侵袭转移的关系  

Relationship between the expression of CEACAM1,CD34 and the metastasis of gastric cancer

作　　者：潘棋 陈艳 向培 黄逸姣 谢楠岚 章烨[2] PAN Qi CHEN Yan XIANG Pei HUANG Yi-jiao XIE Nan-lan ZHANG Ye(Dept. of Integrated Traditional Chinese and Western Medicine, the Second Traditional Chinese Medicine Hospital of Wuxi City Wuxi 214000 Dept. of Integrated Traditional Chinese and Western Medicine, the Fourth People＇s Hospital of Wuxi City, Wuxi 214000, China)

机构地区：[1]无锡市第二中医医院中西医结合肿瘤科,江苏无锡214000 [2]无锡市第四人民医院中西医结合肿瘤科,江苏无锡214000

出　　处：《基础医学与临床》2017年第5期705-708,共4页Basic and Clinical Medicine

摘　　要：目的探讨癌胚抗原相关黏附分子1(CEACAM1)和CD34蛋白表达与胃癌侵袭转移的关系。方法免疫组化SP法检测90例胃癌组织和30名正常胃黏膜组织中CEACAM1及CD34的表达情况,分析CEACAM1和CD34标记的微血管密度(MVD)与胃癌患者临床病理特征的关系。结果 CEACAM1和CD34蛋白在胃癌中的阳性表达明显高于正常胃黏膜组织(P<0.05)。CEACAM1蛋白的表达程度与肿瘤分化、侵袭深度、是否淋巴结转移及病理分期相关(P<0.05),胃癌组织中MVD与肿瘤大小、分化、侵袭深度、是否淋巴结转移及病理分期相关(P<0.05)。CEACAM1表达程度及CD34标记的MVD在胃癌中的表达呈正相关关系(P<0.05)。结论 CEACAM1与CD34参与了胃癌的侵袭和转移,有望成为胃癌发生、发展和预后的预测指标。Objective To investigate the prognostic impact of carcinoembryonic antigen-related cell adhesion molecule 1 （CEACAM1） and CD34 on invasion and metastasis of gastric cancer. Methods CEACAM1 and CD34 expressions were detected by immunhistochemistry in 90 cases of gastric cancer and 30 cases of normal gastric mucosa. Then the relationship among CEACAM1, MVD marked by CD34 antibody and gastric cancer patients＇ clinical pathological features and prognosis were analyzed. Results The positive rates of CEACAM1 and CD34 protein in gastric cancer were significantly higher than those in normal gastric mucosa （ P 〈 0.05 ）. The positive rate of CEACAM1 was closely related to histological differentiation, tumor invasion, nodal metastasis and TNM stage. MVD marked by CD34 was related with tumor size, histological differentiation, tumor invasion, nodal metastasis and TNM stage（P 〈0.05）. Conclusions In gastric cancer, CEACAM1 and CD34 promote its invasion and metastasis, and they are potential indicators of predicting development and prognosis.

关 键 词：癌胚抗原相关黏附分子1 微血管密度 胃癌 免疫组化 

分 类 号：R735.2[医药卫生—肿瘤]