非糜烂性反流病患者胃食管交界顺应性增加  

Increased gastroesophageal junction compliance in patients with non-erosive reflux disease

作　　者：刘继喜[1] 赵树巧 刘芳[1] 李晓讴[1] 李靖涛[1] LIU Ji-xi ZHAO Shu-qiao LIU Fang LI Xiao-ou LI Jing-tao(Dept. of Gastroenterology, China-Japan Friendship Hospital, Beijing 100029 Dept. of Gastroenterology the First Hospital of Shijiazhuang, Shijiazhuang 050500, China)

机构地区：[1]中日友好医院消化内科,北京100029 [2]石家庄第一医院消化内科,河北石家庄050500

出　　处：《基础医学与临床》2017年第5期714-717,共4页Basic and Clinical Medicine

摘　　要：目的揭示非糜烂性反流病(NERD)的生物力学机制。方法纳入自2014年10月4日至2015年9月30日就诊于中日友好医院消化内科门诊符合NERD诊断的17例患者及健康志愿者17名。使用内镜联合Endo Flip技术对胃食管交界的横截面面积(CSA)、球囊内压力和顺应性(Δv/Δp)进行测定。结果随球囊容积增加,胃食管交界处的顺应性NERD组显著高于对照组(P<0.01),而横截面积和球囊内压力变化不明显。结论非糜烂性反流病患者的胃食管交界的顺应性增加可能是其重要的发病机制之一。Objective To explore the biomechanical mechanism of non-erosive reflux disease （NERD）. Methods From October 4,2014 to September 30,2015,17 NERD patients and 17 healthy controls were recruited from the outpatients department of China-Japan Friendship Hospital. The cross-sectional area （CSA） , intra-balloon pressure （IBP） and compliance （△v/△p）of each were measured by endoscopy in combination with EndoFlip. Results With the increase of balloon volume, the compliance of gastroesophageal junction in NERD group was significantly higher than that of control group（P 〈0. 01 ） while the cross sectional area and intra-balloon pressure were similar. Conclusions Increased compliance of the gastroesophageal junction may be involved in the pathogenesis of non-erosive reflux disease.

关 键 词：非糜烂性反流病 顺应性 胃食管交界 

分 类 号：R571[医药卫生—消化系统]