四种蛋白类肿瘤标志物对结直肠癌筛查的价值  

Value of four protein tumor markers in colorectal cancer screening

作　　者：王敏[1] 崔博豪 孙舒雅 杨舒[1] 张雷[2] Min Wang Bo-Hao Cui Shu-Ya Sun Shu Yang Lei Zhang(School of Basic Medicine, Tianjin Medical University, Tianjin 300070, China Department of Thoracic Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China)

机构地区：[1]天津医科大学基础医学院,天津市300070 [2]天津医科大学附属肿瘤医院肺部肿瘤科,天津市300060

出　　处：《世界华人消化杂志》2017年第11期996-1001,共6页World Chinese Journal of Digestology

摘　　要：结直肠癌(colorectal cancer,CRC)是常见的恶性肿瘤之一,占我国恶性肿瘤的第4位,且近年来发病率仍有不断上升的趋势.开展有效的结CRC筛查工作能改善预后,显著降低患者的死亡率,具有重大意义.在众多筛查方式中,粪便与血清中的肿瘤标志物检测技术操作简单,患者痛苦小,费用低,成为研究关注的热点.鉴于肿瘤标志物检测对CRC癌筛查的重要意义,本文对四种主要蛋白质类肿瘤标志物在CRC筛查中的研究现状作一文献综述,以期为临床提供理论依据.Colorectal cancer（CRC） is one of the common malignant tumors worldwide and the fourth most common cancer in China.In recent years the incidence of CRC is still on the rise.It is of great significance to carry out effective screening for CRC with regard to improving prognosis and reducing mortality.Among many screening methods currently available,the detection of tumor markers in feces and serum is easy to operate,inexpensive,and noninvasive,thus becoming the focus of research.In view of the great significance of tumor marker detection for CRC screening,this article discusses the value of four protein tumor markers in CRC screening,with an aim to provide a theoretical basis for their clinical use.

关 键 词：金属蛋白酶1组织抑制剂 转铁蛋白 M2型丙酮酸激酶 结直肠癌 筛查 

分 类 号：R735.34[医药卫生—肿瘤]