藏药灰兜巴治疗糖尿病的研究进展  

Research progress on treatment of diabetes with Tibetan medicine Huidouba

作　　者：杨坤宝[1] 庞宗然[1] 

机构地区：[1]中央民族大学中国少数民族传统医学研究院,北京100081

出　　处：《中草药》2017年第8期1682-1686,共5页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81273912);教育部"长江学者和创新团队发展计划"(IRT_13R63)

摘　　要：糖尿病(diabetes mellitus,DM)是以胰岛素抵抗和β细胞功能的渐进性衰竭为特征表现的代谢紊乱性疾病,以其高发病率、高致残率及高致死率成为世界范围内被广泛关注的严重危害人类健康的重大疑难疾病。传统中医药和民族医药可通过调脂减肥、改善胰岛素抵抗状态、降低低血糖症发生风险治疗2型糖尿病,同时在以血管病变为基础的并发症治疗中具有明显优势。多项研究显示藏药灰兜巴能够在一定程度上改善糖尿病动物血糖、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HLD-C)代谢情况,并能提高其体内超氧化物歧化酶(SOD)活性,降低丙二醛(MDA)水平。其调节糖脂代谢作用机制主要涉及α-葡萄糖苷酶抑制作用、过氧化物酶体增殖物激活受体(PPAR)激动作用及肾组织氧化应激相关酶烟酰胺腺嘌呤二核苷酸磷酸(NADPH)氧化酶抑制作用。Diabetes is a metabolic disorder characterized by insulin resistance and progressive failure of β cell. It becomes a major disease and causes much attention because of high incidence, high disability, and high morbidity. Traditional Chinese medicine and ethical minority medicine have certain effects on diabetes, such as regulating lipid and losing weight, improving insulin resistance, and reducing hypoglycemia risk, and also have obvious advantage in therapy for vascular complication. Studies show that Tibetan Huidouba can improve metabolism of blood glucose, triglyceride（TG）, total cholesterol（TC）, low density lipoprotein cholesterol（LDL-C）, high density lipoprotein cholesterol（HDL-C）, activity of superoxide dismutase（SOD） and malondialdehyde（MDA） content in diabetic animal. The metabolism includes inhibiting α-glycosidase enzyme, activating peroxisome proliferators activated receptors（PPAR）, and inhibiting nicotinamide adenine dinucleotide phosphate coenzyme II（NADPH） oxidase.

关 键 词：藏药 灰兜巴 糖尿病 Α-葡萄糖苷酶 过氧化物酶体增殖物激活受体 烟酰胺腺嘌呤二核苷酸磷酸氧化酶 

分 类 号：R28[医药卫生—中药学]