丹参注射液辅助下治疗急性脑梗死对患者SOD的影响  

Influence of Danshen injection adjunctive treatment on the therapeutic effects and SOD levels in patients with acute cerebral infarction

作　　者：吴文琴[1] 皮海菊[2] 秦雪琴[1] 杨増强 夏俊琳[1] 徐红菊[1] 李小燕[1] WU Wenqin PI Haijv QIN Xueqin et al(Emergency Department, Taihe Hospital of Shiyan City, Hubei, Shiyan 442000, Chin)

机构地区：[1]湖北省十堰市太和医院(湖北医药学院附属太和医院)急诊科,442000 [2]湖北省十堰市太和医院(湖北医药学院附属太和医院)脊柱外科,442000

出　　处：《河北医药》2017年第10期1445-1448,共4页Hebei Medical Journal

基　　金：湖北省自然科学基金资助项目(编号:2013FFB04610)

摘　　要：目的研究丹参注射液辅助治疗急性脑梗死对患者的临床疗效及SOD的影响。方法选取2014年1月至2015年1月收治的脑梗死患者132例,按照随机数表法将研究对象划分为观察组和对照组,每组66例。所有患者采取阿替普酶进行治疗,观察组患者在此基础上联合丹参注射液。比较2组患者治疗前后神经功能缺损程度、脑梗死灶体积、神经元特异性烯醇化酶(NSE)、血浆内皮素(ET)、超氧化物歧化酶(SOD)变化,观察2组患者治疗3周后生活质量改善情况和临床疗效。结果治疗后,观察组患者NIHSS评分[(7.52±4.05)分]和脑梗死体积[(11.56±4.77)cm^3]显著低于对照组,观察组患者临床疗效(84.85%)显著高于对照组(63.64%),观察组患者SOD活力[(101.34±12.74)n U/ml]显著高于对照组[(93.58±10.87)n U/ml],并且ET含量[(56.99±7.87)pg/ml]及NSE浓度[(20.42±5.45)ng/ml]显著低于对照组,观察组患者生活质量改善程度显著优于对照组,差异有统计学意义(P<0.05)。治疗前后2组患者凝血功能差异无统计学意义(P>0.05)。结论阿替普酶联合丹参注射液能明显改善脑梗死患者的神经功能缺损程度,减少脑梗死体积,改善SOD、ET、NSE指标,其效果良好,值得广泛推广使用。Objective To investigate the influence of Danshen injection adjunctive treatment on the therapeutic effects and superoxide dismutase（ SOD） levels in patients with acute cerebral infarction（ ACI）. Methods One hundred and thirty-two patients with ACI who were admitted and treated in our hospital from January 2014 to January 2015 were divided into observation group（ n = 66） and control group（ n = 66） according to random number table. The patients in control group were treated by alteplase,the patients in observation group,on the basis of control group,were treated by Danshen injection.The neurological function defect degree,cerebral infarction volume,neuron-specific enolase（ NSE）,plasma endothelin（ ET）,SOD before and after treatment were observed and compared between two groups. Moreover the improvement status of patient＇s life quality and therapeutic effects after 3-week treatment were observed and compared between two groups. Results After treatment,the NIHSS scores（ 7. 52 ± 4. 05） points and infarction volume（ 11. 56 ± 4. 77） cm^3 in observation group were significantly lower than those in control group,and the clinical curative effect（ 84. 85%） in observation group was significantly higher than that（ 63. 64%） in control group. The SOD activity（ 101. 34 ± 12. 74） n U/ml in observation group was significantly higher than that（ 93. 58 ± 10. 87） n U/ml in control group,however ET content（ 56. 99 ± 7. 87） pg/ml and NSE concentration（ 20. 42 ± 5. 45） ng/ml were significantly lower than those in control group,moreover the improvement degree of patient＇s life quality in observation group was superior to that in control group（ P〈0. 05）,but there was no significant difference in blood coagulation function before and after treatment between two groups（ P〉0. 05）. Conclusion The alteplase combined with Danshen injection can significantly improve nerve function impairment in patients with cerebral infarction,and can reduce cerebral infarction volume

关 键 词：阿替普酶 丹参注射液 脑梗死 

分 类 号：R743.33[医药卫生—神经病学与精神病学]