血小板相对变化度与脓毒症患者病情严重程度及预后的关系  

Relationship between the relative variability of blood platelet count and the severity and prognosis of sepsis

作　　者：潘思梦 刘玉静[2] 贺黉裕[1] 郑毅隽[1] 诸杜明[1] 罗哲[1] 居旻杰[1] 

机构地区：[1]复旦大学附属中山医院重症医学科,上海200032 [2]复旦大学附属中山医院护理部,上海200032

出　　处：《中国临床医学》2017年第2期286-289,共4页Chinese Journal of Clinical Medicine

基　　金：复旦大学附属中山医院人才培养计划-优秀青年计划(2015ZSYXQN29)~~

摘　　要：目的:探讨外周血血小板计数的变化度与脓毒症患者病情及预后的关系。方法:收集2015年3月至2016年6月复旦大学附属中山医院重症医学科(ICU)收治的102例脓毒症患者的相关临床资料。比较血小板相对变化度高低患者相关临床特征的差异,分析血小板相对变化度与病情严重程度及患者死亡率的关系。结果:患者的血小板相对变化度与患者入ICU时的急性生理与慢性健康评分Ⅱ(r=-0.397,P<0.001)、脓毒症相关性器官功能衰竭评分(r=-0.317,P=0.001)评分负相关。多因素回归分析显示,血小板相对变化度是脓毒症患者ICU死亡的独立预测因素(OR=0.174,95%CI 0.040~0.758,P=0.02)。结论:脓毒症患者外周血血小板计数的变化程度能较好地反映疾病严重程度,且与患者ICU死亡率密切相关。Objective： To evaluate the relationship between the relative variability of the platelet count in peripheral blood and the severity and prognosis of sepsis patients. Methods ： Clinical data of 102 sepsis patients admitted to the Department of Critical Care Medicine （ICU） , Zhongshan Hospital, Fudan University from March 2015 to June 2016 were collected. The clinical characteristics of patients with high and low platelet relative variability were compared. The relationship between the relative variability of blood platelet count and the severity of disease and mortality were analyzed. Results ： The relative variability of the platelet count was negatively associated with the SOFA （Spearman r = -0.317,P = 0. 001） and APACHE TT （Spearman r= -0. 397,P〈0. 001） scores upon admission into ICU. Multivariate regression analysis showed that the relative variability of platelet count was an independent predictor of ICU mortality in sepsis patients （OR=0.174, 9S% CI 0. 040-0. 758, P=0.02）. Conclusions： The relative variability of platelet count in sepsis patients can reflect the severity of the disease and predict the ICU mortality of these patients.

关 键 词：脓毒症 血小板计数 相对变化度 死亡率 

分 类 号：R364.5[医药卫生—病理学]