结直肠癌肿瘤干细胞标志物的研究进展  

Research progress of cancer stem cell markers in colorectal cancer

作　　者：袁杭[1,2] 刘斌[1,2,3] 辛晴[1,4] 孙亚敏[1,4] 

机构地区：[1]中国人民解放军兰州军区兰州总医院病理科,甘肃兰州730050 [2]兰州大学基础医学院病理研究所,甘肃兰州730030 [3]甘肃省干细胞与基因药物重点实验室,甘肃兰州730050 [4]甘肃中医药大学基础医学院,甘肃兰州730000

出　　处：《现代肿瘤医学》2017年第11期1834-1837,共4页Journal of Modern Oncology

摘　　要：肿瘤干细胞与恶性肿瘤复发、耐药等生物学过程密切相关,是治疗恶性肿瘤的新靶点。寻找稳定性高、特异性强、实用性好的肿瘤干细胞标志物,清除恶性肿瘤中的肿瘤干细胞有望彻底根治恶性肿瘤。本文综述了结直肠癌中比较公认的肿瘤干细胞标志物CD44和潜在的肿瘤干细胞标志物LGR5、Bmi1、SOX2、Nanog的研究进展,为靶向治疗结直肠癌提供了参考依据。Tumor stem cells are closely related to the biological processes such as relapse and drug resistance,and have become a new target for the treatment of malignant tumor. Looking for high s tability, spe cif icity and practica bili-ty tumor stem cell markers, removal of cancer stem cells from malignant tumors is expected to completely cure malig-nant tumors. This paper reviews the research progress of CD44 which is a putative tumor stem cell marker and LGR5 ,Bmil,SOX2, Nanog which are potential tumor stem cel l markers in colorectal cancer, to provide reference for targe-ted therapy of colorectal cancer.

关 键 词：结直肠癌 肿瘤干细胞标志物 CD44 LGR5 BMI1 SOX2 NANOG 

分 类 号：R735.3[医药卫生—肿瘤]