健脾祛湿解毒复方对晚期大肠癌化疗影响的荟萃分析  

The influence of Jianpi Qushi Jiedu compound on the chemotherapy of advanced colorectal cancer: a meta analysis

作　　者：刘珊珊[1] 石齐[1] 李泓佳 李文[1] 宗绍其 任建琳[1] 侯风刚[1] 

机构地区：[1]上海中医药大学附属市中医医院,上海200071

出　　处：《现代中西医结合杂志》2017年第15期1597-1600,1634,共5页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：上海市卫生局科委基金资助项目(20134117;2014LZ079A);上海市教委科创引导项目(14401930800)

摘　　要：目的研究健脾祛湿解毒复方对晚期大肠癌化疗的影响。方法计算机检索中国知网(CNKI)、维普(VIP)、万方(Wanfang Data)、SinoMed、PubMed数据库2000年1月—2016年9月发表的健脾祛湿解毒复方联合化疗与单纯化疗比较治疗晚期大肠癌的临床随机对照试验,采用Stata14.0软件进行统计分析。结果共纳入9个RCT研究,对416例患者进行分析。Meta分析结果显示:健脾祛湿解毒复方联合化疗的肿瘤客观缓解率[OR=1.66,95%CI(1.10,2.50)]、中医症状疗效[OR=4.04,95%CI(2.48,6.59)]、生活质量[SMD=1.28,95%CI(0.83,1.72)]均明显优于单纯化疗(P均<0.05),白细胞下降[RR=0.70,95%CI(0.58,0.84)]、恶心呕吐[RR=0.64,95%CI(0.52,0.79)]、腹泻[RR=0.66,95%CI(0.50,0.88)]发生率均明显低于单纯化疗(P均<0.05)。2组癌胚抗原水平及神经毒性发生率比较差异均无统计学意义(P均>0.05)。结论与单纯化疗相比,健脾祛湿解毒复方联合化疗能够提高肿瘤客观疗效及中医症状疗效,减轻化疗的部分不良反应,改善患者的生活质量,但对降低癌胚抗原和神经毒性发生率的作用并不明显。Objective It is to evaluate the influence of Jianpi Qushi Jiedu compound （JPQSJD） on the chemotherapy of advanced colorectal cancer. Methods The randomized controlled trails （RCT） about the comparison between JPQSJD com-bined with chemotherapy and single chemotherapy, which were published from January 2000 to December 2015, were retrieved from CNKI, VIP, Wanfang Data, SinoMed and PubMed databases by computer. SATA14. 0 software was used for statistical a-nalysis. Results 9 RCT containing 416 patients were adopted for this meta-analysis. Meta-analysis showed： objective response rate （ ORR） [ OR = 1.66, 95% Cl （1. 10, 2. 50） ] , therapeutic effects of symptoms defined by traditional Chinese medicine （TCM） [OR =4.04, 95% Cl （2.48, 6.59）] , the living quality [SMD = 1.28, 95% Cl （0.83, 1.72） ] of patients treated with combination of JPQSJD and chemotherapy were significantly better than with simple chemotherapy （ all P 〈 0. 05 ） ; and the incidence of leukopenia [ RR = 0. 70, 95% Cl （0. 58, 0. 84） ] , nausea and vomiting [ RR = 0. 64, 95% Cl （0. 52, 0. 79） ] , and diarrhea [ RR = 0. 66, 95% Cl （0. 50, 0. 88） ] of patients treated by combination of JPQSJD and chemotherapy were significantly lower than with simple chemotherapy （all P 〈0. 05） . There was no significant difference in reducing carcino embryonic antigen （ CEA） and the incidence of neurotoxic reactions between the both groups. Conclusion Compared with chemotherapy alone, JPQSJD combined with chemotherapy got a better ORR, alleviate adverse reactions of chemotherapy partly ,improve the symptoms defined by TCM, increase the living quality, while it cannot reduce CEA and the incidence of neu-rotoxic reactions observably.

关 键 词：健脾祛湿解毒复方 化疗 晚期大肠癌 荟萃分析 

分 类 号：R735.3[医药卫生—肿瘤]