舒筋通络颗粒矫味剂的筛选与评价  

Screening and evaluation of the flavors of Shujintongluo Granules

作　　者：姜国志 屈云萍 李哲 陈翔宇 李龙龙 陈钟 

机构地区：[1]神威药业集团有限公司,石家庄051430 [2]中药注射剂新药技术开发国家地方联合工程实验室,石家庄051430

出　　处：《西北药学杂志》2017年第3期337-340,共4页Northwest Pharmaceutical Journal

基　　金：石家庄市科学技术研究与发展计划项目(编号:20013A)

摘　　要：目的优选舒筋通络颗粒最佳矫味工艺和处方,并对其矫味效果进行综合评价。方法先采用正交实验对影响口味的乳香挥发油进行β-环糊精包合工艺优化,再采用模糊数学对处方中矫味剂的用量及工艺综合评价。结果乳香挥发油包合优化参数为:挥发油和β-环糊精的投料比为1∶8,包合温度为60℃,包合时间为180min;最佳矫味剂处方用量为0.015g·g^(-1)三氯蔗糖和0.01g·g^(-1) L-苹果酸。结论模糊数学可用于舒筋通络颗粒矫味工艺和处方的筛选,优化后的处方和工艺完全具备产业化生产条件,同时也符合相关法规要求。Objective To optimize the process and prescription of Shujintongluo Granules,and to make a comprehensive evaluation on the effect of taste-modification.Methods By using orthogonal test,theβ-cyclodextrin inclusion process of Boswellia carterii volatile oil was optimized.Fuzzy mathematics was adopted to evaluate the prescription taste-modification dosage and process.Results The optimized parameters of theβ-cyclodextrin inclusion process of Boswellia carterii volatile oil were as follows：the ratio of Boswellia carterii volatile oil toβ-cyclodextrin was 1∶8,the inclusion temperature was 60 ℃,the inclusion time was 180min;the optimal prescription was 0.015g·g-1 sucralose,and 0.01g·g-1 L-malic acid.Conclusion The fuzzy mathematics can be used for the screening the taste-modification prescription in Shujintongluo Granules.Not only the optimized prescription and process could be applied under the industrial production conditions,but also meet the requirements of relevant laws and regulations.

关 键 词：舒筋通络颗粒 Β-环糊精 矫味剂 模糊数学 正交实验 

分 类 号：R94[医药卫生—药剂学]