参杞红玛胶囊的急性毒性及遗传毒性  

Acute toxicity and genetic toxicity test of Ginseng Wolfberry Rhodiola Maca Capsule

作　　者：洪丽华[1] 杨卫超[1] 张俊刚[1] 左派欣[1] 徐颖[1] 

机构地区：[1]河北省疾病预防控制中心卫生毒理所,河北石家庄050021

出　　处：《职业与健康》2017年第5期613-615,共3页Occupation and Health

摘　　要：目的研究参杞红玛胶囊的急性毒性和遗传毒性。方法采用最大耐受剂量法的大、小鼠经口急性毒性试验、遗传毒性试验(Ames试验、小鼠骨髓细胞微核试验、小鼠精子畸形试验)。结果两种性别的大、小鼠经口最大耐受剂量(MTD)均大于15 000 mg/kg。3项遗传毒性试验结果均为阴性。结论在实验条件下,参杞红玛胶囊属无毒级,未见遗传毒性。[Objective]To study the acute toxicity and genotoxicity of Ginseng Wolfberry Rhodiola Maca（GWRM）capsule.[Methods]Acute toxicity test for rats and mice by maximum dose method,and genetic toxicity test（Ames test,micronucleus test of bone marrow cell in mice,sperm shape abnormality test in mice） were made.[Results]The oral maximum dose（MTD） for rats and mice was more than 15 000 mg/kg. All 3 genetic toxicity tests had negative results.[Conclusion]GWRM shows neither acute toxicity nor genetic toxicity under experimental conditions.

关 键 词：参杞红玛胶囊 大鼠、小鼠 急性毒性试验 遗传毒性试验 

分 类 号：R114[医药卫生—卫生毒理学]