幽门螺旋杆菌引起胃黏膜免疫损伤机制研究进展  

New insights about induced by Helicobacter pylori the immune injury of gastric mucosa

作　　者：张海莲[1] 朱云[2] 刘军权[3] 王金春[4] 

机构地区：[1]蚌埠医学院,233000 [2]中国人民解放军第97医院消化科,徐州221004 [3]中国人民解放军第97医院生物治疗中心,徐州221004 [4]沭阳县人民医院消化科,宿迁223600

出　　处：《国际免疫学杂志》2017年第2期204-209,共6页International Journal of Immunology

基　　金：南京军区医学科技创新课题（011Z009）

摘　　要：幽门螺旋杆菌（Helicobacter plyori，Hp）是消化道疾病最常见的病因，通过多种机制诱导炎症通路激活、免疫细胞及炎症因子释放改变胃黏膜周围微环境引起慢性炎症，持久性的慢性炎症可导致胃黏膜萎缩、甚至诱发胃癌。正常机体T淋巴细胞在免疫反应中起主导作用，其中正向调节与负向调节系统相互诱导和制约T细胞网络维持免疫系统平衡，当Hp感染后两项调节比例出现异常，导致免疫系统紊乱从而引起免疫损伤。近年来免疫细胞的分子生物学研究已经成为临床过继性细胞免疫治疗的理论基础。Helicobacter pylori（HP） is the most common causative gastrointestinal pathogen, Hp can in- duce inflammation through various inflammation pathways activated cytokines. The semechanisms can cause chronic inflammation of gastric. The persistence of chronic inflammation can lead to gastric mucosa atrophy and even induce gastric cancer. T cells play a leading role in the immune response. There are the positive and the negative adjustment systems to restrict T cells and to maintain the immune system balance. When the two adjusting systems are imbalanced after Hp infection,it can lead to immune system disorders. In addition. The molecu- lar biology of immune cells has become the basis of adoptive cellular immunotherapy in recent years.

关 键 词：幽门螺旋杆菌 分子生物学 免疫细胞 

分 类 号：R573[医药卫生—消化系统]