脑蛋白水解物对缺血性脑血管病患者血流动力学及神经功能的影响  

Effects of Brain Protein Hydrolysate on Hemodynamics and Neural Function of Patients with Ischemic Cerebrovascular Disease

作　　者：解建国[1] 薛艺东[1] 屈文英[1] 高亚军[1] 刘峰[1] 王妍妮[2] 

机构地区：[1]延安大学附属医院神经内科,陕西延安716000 [2]延安大学附属医院肾内科,陕西延安716000

出　　处：《现代生物医学进展》2017年第14期2725-2728,共4页Progress in Modern Biomedicine

基　　金：陕西省自然科学基础研究计划项目(2012JM4004)

摘　　要：目的:探讨脑蛋白水解物对缺血性脑血管病患者血流动力学、血脂水平及神经功能的影响。方法:92例缺血性脑血管病患者依据抽签法分作对照组与观察组,各46例,对照组采用常规治疗,观察组在常规治疗基础上结合脑蛋白水解物治疗,观察并比较两组患者的全血低切黏度、全血高切黏度、血浆黏度、红细胞压积、纤维蛋白原、总胆固醇(TC)、甘油三脂(TG)、低密度脂蛋白(LDL-C)高密度脂蛋白(HDL-C)、神经功能、脑血管储备能力、屏气指数以及临床效果。结果:治疗后,两组血流动力学均低于治疗前,且观察组低于对照组(P<0.05);两组TC、TG、LDL-C均低于治疗前,且观察组低于对照组(P<0.05);两组HDL-C均高于治疗前,且观察组高于对照组(P<0.05);两组NIHSS均低于治疗前,且观察组低于对照组(P<0.05);两组脑血管储备能力及屏气指数均高于治疗前,且观察组高于对照组(P<0.05)。观察组治疗有效率高于对照组,差异具有统计学意义(P<0.05)。结论:脑蛋白水解物可有效调节缺血性脑血管病患者血流动力学及血脂水平,改善神经功能。Objective： To study the effects of brain protein hydrolysate on hemodynamics, blood lipid levels and neural function in patients with ischemic cerebrovascular disease. Methods： 92 patients with ischemie cerebrovascular disease who were treated in our hospital were selected and randomly divided into the control group and the observation group, with 46 cases in each group. The patients in the control group were treated with the conventional method, while the patients in the observation group were treated with the brain protein hydrolyzate on the basis of the conventional treatment. Then the levels of the whole blood low shear viscosity, whole blood high shear viscosity, plasma viscosity, erythrocyte pressure volume, fibrinogen, total cholesterol （TC）, triglycerides （TG）, low density lipoprotein （LDL-C） and high density lipoprotein （HDL-C） and the nerve function, cerebrovascular reserve capacity, breathless index and the clinical effect in the two groups were observed and compared before and after the treatment. Results： After treatment, the hemodynamics of the two groups were significantly lower than before, and the observation group was lower than that of the control group （P 〈0.05）; the levels of TC, TG and LDL-C in the two groups were lower than before, and the observation group was lower than that of the control group （P〈0.05）; the levels of HDL-C in the two groups were higher than before, and the observation group was higher than that of the control group （P〈0.05）; the NIHSS in the two groups were lower than before, and the observation group was lower than that of the control group （P〈0.05）; the cerebrovascular reserve capacity and breath holding index of the two groups were higher than before, and the observation group were higher than those of the control group （P〈0.05）. The effective rate in the observation group was higher than that of the control group （P〈0.05）. Conclusion： Brain protein hydrolyzate can effectively regulate hemodynamics and blood

关 键 词：缺血性脑血管病 脑蛋白水解物 血流动力学 神经功能 

分 类 号：R743[医药卫生—神经病学与精神病学]