Cdc42介导的主动遗忘过程对重复学习效应的调节机制  

Cdc42-Dependent Forgetting Regulates Repetition Effect in Prolonging Memory Retention

作　　者：Xuchen Zhang Qian Li Lianzhang Wang Zhong-Jian Liu 钟毅[2] 

机构地区：[1]不详 [2]清华大学生命科学学院

出　　处：《科学新闻》2017年第4期149-149,共1页Science News

基　　金：973项目;国家自然科学基金委项目的资助

摘　　要：重复学习可以提高记忆力是生物中普遍存在的现象。之前，心理学家和生物学家普遍认为，重复学习之所以能够提高记忆力，是因为重复学习增强了学习效果。Repeated learning is used daily and is a powerful way to improve memory. A fundamental question is how multiple learning trials add up to improve memory. While the major studies so far of such a repetition effect have emphasized the strengthening of memory formation, the current study reveals a molecular mechanism through suppression of forgetting. We find that single-session training leads to formation of anesthesia-resistant memory (ARM) and then activation of the small G protein Cdc42 to cause decay or forgetting of ARM within 24 hr. Repetition suppresses the activation of Cdc42-dependent forgetting, instead of enhancing ARM formation, leading to prolonged ARM. Consistently, inhibition of Cdc42 activity through genetic manipulation mimicked the repetition effect, while repetition-induced ARM improvement was abolished by elevated Cdc42 activity. Thus, only the first session in repetitive training contributes to ARM formation, while the subsequent sessions are devoted not to acquiring information but to inhibiting forgetting.

关 键 词：学习效应 调节机制 遗忘 生物学家 心理学家 学习效果 记忆力 普遍 

分 类 号：B842.3[哲学宗教—基础心理学]