NF-κB对非酒精性脂肪性肝病发病过程的影响  

Effect of NF-κB on the pathogenic course of non-alcoholic fatty liver disease

作　　者：伍莉[1] 谢玉桃[1] 

机构地区：[1]中南大学湘雅医院感染病科,长沙410008

出　　处：《中南大学学报（医学版）》2017年第4期463-467,共5页Journal of Central South University ：Medical Science

摘　　要：随着经济的发展和人们生活水平的提高,非酒精性脂肪性肝病(non-alcoholic fatt y liver disease,NAFLD)在全球范围内的患病率明显提高。NAFLD本质上是一种慢性炎症性疾病。NF-κB作为一种转录因子,参与机体的炎症反应、免疫反应、细胞增殖及凋亡过程,可以通过胰岛素抵抗、氧化应激、肠道菌群失调及活化肾素-血管紧张素系统等机制促进NAFLD的发生与发展。With the economic growth and better standards of living, the prevalence of non-alcoholic fatty liver disease （NAFLD） is expected to increase dramatically worldwide. NAFLD is a common chronic inflammation disease. NF-κB is a transcription factor that plays crucial roles in inflammation, immunity, cell proliferation and apoptosis. It can facilitate the occurrence and development of NAFLD, and the underlying mechanisms are related to insulin resistance, oxidative stress, alteration of intestinal flora, activation ofrenin angiotensin system, etc.

关 键 词：非酒精性脂肪性肝病 NF-ΚB IΚB激酶 炎症 纤维化 

分 类 号：R575[医药卫生—消化系统]