上皮干细胞参与肿瘤恶变的机制  

Involvement of epithelial stem cells in malignant transformation and mechanisms

作　　者：张诗惠 胡琼[2] 谢富安 洪笑迁 刘宽灿[2,3] 

机构地区：[1]中南大学本科生院,长沙410083 [2]厦门大学附属东方医院检验科,福州350025 [3]福州总医院全军临床检验医学研究所,350025

出　　处：《中华细胞与干细胞杂志（电子版）》2017年第2期112-116,共5页Chinese Journal of Cell and Stem Cell（Electronic Edition）

基　　金：国家自然科学基金(81302068);国家863青年科学家专题(2014AA020541);福建省国际合作重点项目(2017I0014)

摘　　要：上皮干细胞是一类具有自我更新能力和多向分化潜能的细胞,在维持上皮稳定中起到关键作用。随着研究不断深入,发现上皮干细胞可作为上皮肿瘤发生的起始细胞,上皮干细胞恶变不仅受干细胞微环境影响,它还与多条信号通路失调及基因突变相关。但上皮干细胞如何恶变为肿瘤的具体机制依旧不清楚。本文就上皮干细胞和肿瘤干细胞两者的联系以及上皮干细胞恶变为肿瘤的作用机制进行阐述。Epithelial stem cells, which have the ability of self-renewal and multiple differentiation, play a crucial role in maintaining epithelial tissue homeostasis. Recently, many studies have showed that epithelial stem cells may be the tumour-initiating cells. The transformation of epithelial stem cell is not only affected by the microenvironment, but also promoted by dysregulation of signal pathways and gene mutations. However, the mechanism how epithelial stem cells transform and become tumor cells remains unclear. Here we review the relationships between epithelial stem cells and cancer stem cells and the mechanism of transformation of epithelial stem cells.

关 键 词：上皮细胞 肿瘤干细胞 机制 

分 类 号：R730.2[医药卫生—肿瘤]