抑郁症患者大脑局部一致性静息态磁共振成像的meta分析  

Regional homogeneity in depression：a meta.analysis of resting-state functional-MRI studies

作　　者：李业宁 张爱霞[1] 张克让[1] 

机构地区：[1]山西医科大学第一医院精神卫生科,太原030001 [2]山西医科大学医学心理学教研室,太原030001

出　　处：《中华行为医学与脑科学杂志》2017年第4期379-384,共6页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金项目（81471379）;山西省应用基础研究青年基金项目（201601D021151）

摘　　要：目的针对抑郁症静息态局部一致性fMRI研究结果进行有效联合得出一致结果。方法在Pubmed，Web of knowledge和EBSCO host medline数据库以及中国知网、万方数据库、维普知识仓储检索2003—2016年间相关抑郁症fMRI文献，按照纳入与排除标准筛选文献后用AES—SDM进行系统元分析，并对年龄、性别、疾病持续时间、受教育年限、治疗情况进行回归分析。结果23篇文献符合标准，样本量总计1036例，其中抑郁组507例，对照组529例。元分析显示默认网络中左侧楔前叶，左侧前额回，右侧扣带回ReHo显著异常，此外豆状核，左侧中央后回，左侧小脑，左侧梭状回也是异常脑区。回归分析中，性别，年龄，疾病持续时间，受教育年限，疾病严莺程度均为影响因素，且疾病持续时间显著影响扣带回区域（SDM=2．777）。结论默认网络中左侧楔前叶，左侧前额回，右侧扣带回等异常在抑郁症患者fMRI研究中最为一致，默认网络异常与抑郁症密切相关。Objective To effectively combine the resuhs of resting state regional homogeneity （ReHo） fMRI studies in depression. Methods Literatures between 2003-2016 on fMRI of depression in PubMed, Web of Knowledge, EBSCO host medline, CNKI, CQVIP and Wanfang Med Online were taken as research objects.Screening the relevant data according to the included and excluded standard, then, software of AES-SDM was employed to do Meta analysis, in addition, the age, gender, duration of disease, the year of education and treatment were also analyzed. Results 23 articles met the standard, including 1 036 cases, of which 507 for the depression group, 529 for the control group. Meta analysis showed the significant ReHo abnormalities of Default Mode Network （DMN） which centers on left precuneus, left superior frontal gyms and right cingulate gyms,in addition, left lenticular nucleus, left postcentral gyms, left cerebellum and left fusiform gyrus had significant ReHo differences. In the regression analysis, gender, age, duration of disease, years of education, disease severity were all affected factors. The difference of eingulate gyrus was the most stable, and the duration of the disease significantly affected eingulate gyrus （SDM = 2.777）. Conclusion The abnormalities of DMN which centers on left precuneus, left, medial superior frontal gyrus and right cingulate gyrus are the most consistent in depression, the DMN is closely related to depression.

关 键 词：功能磁共振 META分析 AES-SDM 抑郁症 

分 类 号：R749.4[医药卫生—神经病学与精神病学]