口炎清对复发性口腔溃疡患者口腔菌群及细胞免疫功能的影响  

Effect of Kouyanqing on Oral Bacteria Group and Cellular Immunity of Patients with Recurrent Oral Ulcer

作　　者：季育[1] 

机构地区：[1]丽水市中医院口腔科,浙江丽水323000

出　　处：《新中医》2017年第5期104-106,共3页New Chinese Medicine

摘　　要：目的:观察口炎清对复发性口腔溃疡的临床疗效及其对复发性口腔溃疡患者口腔菌群及细胞免疫功能的影响。方法:将纳入标准的73例患者随机分为2组,对照组给予维生素支持治疗,在此基础上予以盐酸左旋咪唑片治疗,治疗组在对照组治疗方案的基础上加用口炎清治疗;观察2组患者临床疗效、口腔菌群含量、外周淋巴细胞增殖及分布情况。结果:2组临床疗效比较,差异有统计学意义(P<0.05),治疗组优于对照组。2组链球菌、韦荣氏菌含量比较,差异均有统计学意义(P<0.05);治疗组能提高链球菌、韦荣氏菌的含量。治疗组外周淋巴细胞在10、20、30μg/m L浓度的PHA诱导下,外周淋巴细胞增殖能力OD值分别与对照组比较,差异均有统计学意义(P<0.05,P<0.01);T细胞总数(CD3+)、T辅助细胞(CD4+)及自然杀伤NK细胞(CD56+)比例以及CD4+/CD8+分别与对照组比较,差异均有统计学意义(P<0.05)。结论:口炎清对复发性口腔溃疡有一定疗效,且能调节口腔菌群比例,提高患者细胞免疫功能。Objective：To observe the clinical effect of Kouyanqing on oral bacteria group and its effect on cellular immunity of patients with recurrent oral ulcer. Methods：Selected 73 patients with recurrent oral ulcer and divided them into two groups randomly. The control group was given vitamin and levamisole hydrochloride tablets additionally,and the treatment group was given Kouyanqing based on the treatment of the control group. Observed clinical effect, content of oral bacteria group,peripheral blood lymphocytes proliferation and its distribution of the two groups. Results ：Compared clinical effect of the two groups,the difference being significant（P〈0.05）,and clinical effect of the treatment group was better than that of the control group. Compared content of streptococcus and verillonella of the two groups,the difference being significant（P〈0.05）,and the treatment group can improve content of streptococcus and verillonella. Compared peripheral lymphocytes proliferation ability optical density（OD） value of the peripheral lymphocytes in the treatment group,which was under the induction of PHA whose concentration was 10, 20 or 30 μg/mL with those of the control group, the difference being significant（P〈0.05）.Compared the proportion？of the total sum of CD3＋T cell,T helper cell（CD4＋）,and Natural killer cell（CD56＋）,and the ratio of CD4＋/CD8＋ in the treatment group with those in the control group,the difference being significant（P〈0.05）. Conclusion：Kouyanqing has certain efficacy in treating recurrent oral ulcer,which can regulate proportion of oral bacteria group and improve cellular immunity of patients.

关 键 词：复发性口腔溃疡 中医疗法 口炎清 口腔菌群 细胞免疫 外周淋巴细胞增殖能力 

分 类 号：R781.5[医药卫生—口腔医学]