肺癌患者自身抗体与肿瘤标志物相关性分析  

Correlation between autoantibodies and tumor markers in patients with lung cancer

作　　者：张红军[1] 房延凤[1] 刘伟[1] 谢永宏[1] 金发光[1] 顾兴[1] 

机构地区：[1]第四军医大学唐都医院呼吸与危重症医学科,西安710038

出　　处：《中华肺部疾病杂志（电子版）》2017年第2期141-145,共5页Chinese Journal of Lung Diseases(Electronic Edition)

基　　金：国家自然科学基金资助项目(81071933)

摘　　要：目的探讨肺癌自身抗体与肿瘤标志物之间的相互关系。方法收集2016年9月至2016年12月收治于第四军医大学唐都医院呼吸内科的肺癌患者112例,分别采用酶联免疫吸附实验法和电化学发光免疫分析法检测肺癌患者7种自身抗体和5种血清学肿瘤标志物的水平,对所得患者自身抗体P53、PGP9.5、SOX2、GAGE7、GBU4-5、MAGE和CAGE,以及肿瘤标志物CEA、SCC、CA125、NSE和CYFRA21-1,的数据进行spearman相关性检验分析。结果不同病理类型肺癌患者的自身抗体水平,肺腺癌患者GAGE7中位数为7.30 U/ml,明显高于鳞癌、小细胞癌等其他类型的肺癌患者(P=0.041),而P53、PGP9.5、SOX2、GBU4-5、MAGE和CAGE水平则无统计学差异。传统的肿瘤标志物CEA和CA125在肺腺癌中、SCC在肺鳞癌中明显升高(P值均<0.05)。经spearman相关性检验分析,在肺癌中,P53与CEA、SCC呈正相关(P值分别为0.024,0.016),PGP9.5与NSE呈正相关(P<0.001),GBU4-5与SCC、CA199呈正相关(P值分别<0.001,=0.011),MAGE与SCC、CA199呈正相关(P值分别=0.004,<0.001)。结论肺癌患者自身抗体与肿瘤标志物存在正相关,同时检测二者可相互补充,更益于肺癌的及时诊断。Objective The levels of autoantibodies （P53, PGP9.5, SOX2, GAGE7, GBU4-5 and MAGE） and tumor markers （CEA, SCC, CA125, NSE and CYFRA21-1） were studied in patients with lung cancer, to explore their correlation between autoantibodies and tumor markers in lung cancer. Methods To collected 112 cases of patients with lung cancer were recruited in Department of Respiratory Medicine Tang Du Hospital the Fourth Military Medical University from September 2016 to December 2016. The autoantibodies P53, PGP9.5, SOX2, GAGE7, GBU4-5 and MACE were measured by Enzyme-linked immunosorbent assay （ELSA）. And their CEA, SCC, CA125, NSE and CYFRA21-1 were measured by Electro-Chemiluminescence Immunoassay （ECLI）. Then the relations between Autoantibodies and Tumor Markers were analyzed by spearman correlation test. Results By analyzing the levels of autoantibodies in patients with different pathological types of lung cancer, the median of GAGE7 is 7.30 U/ml in Lung adenocarcinoma patients, the result was significantly higher than squamous cell carcinoma, small cell carcinoma and other types of lung cancer patients （P = 0.041）. But P53, PGP9.5, SOX2, GBU4-5, MAGE and CAGE were no statistical difference. CEA and CA125 in lung adenocarcinoma, and SCC in lung squamous cell carcinoma were significantly increased（P〈0.05）. There were positive correlations between P53 and CEA and SCC （P=0.024, 0.016, respectively）, between PGP9.5 and NSE （P〈0.O01）, between GBU4-5 and SCC and CA199 （P〈 0.001, 0.011, respectively） , between MAGE and SCC and CA199 （P = 0. 004, 〈 0.001, respectively）.Conclusion There was a positive correlation between autoantibodies and tumor markers. The both complement each other and more conducive to timely diagnosis of lung cancer.

关 键 词：自身抗体 肿瘤标志物 支气管肺癌 

分 类 号：R734.2[医药卫生—肿瘤]